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    Home > Medical News > Latest Medical News > Research on Collaborative Innovation Development of Biomedicine Industry in Guangdong-Hong Kong-Macao Greater Bay Area

    Research on Collaborative Innovation Development of Biomedicine Industry in Guangdong-Hong Kong-Macao Greater Bay Area

    • Last Update: 2021-03-22
    • Source: Internet
    • Author: User
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    The Guangdong-Hong Kong-Macao Greater Bay Area is an important area where my country’s biomedical industry gathers.
    It has a complete industrial foundation and leading strength.
    With the development of the Guangdong-Hong Kong-Macao Greater Bay Area and many other national strategies, the development of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area is entering a new stage of integrated and coordinated development.
    In this article, the author mainly starts from the perspective of regional collaborative innovation, focusing on analyzing the development pattern of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area, and summarizing the regional industrial collaborative innovation development experience, in order to provide reference for local governments, parks and industrial investors.
     
    1.
    The development pattern of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area
     
    A development pattern driven by Guangzhou and Shenzhen, supported by Hong Kong, Macau, Zhuhai, Foshan, and Zhongshan, and supported by Dongguan, Huizhou, Jiangmen, and Zhaoqing, has taken shape, with a sound industrial foundation.
    In recent years, the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area has been advancing in depth in a new round of regional waves centered on the layout of innovative resources.
    The scale of the industry has continued to grow, the industrial system has become more and more perfect, the industrial strength is leading the country, and the agglomeration effect has become increasingly international.
    The degree continues to increase.
    At present, the Guangdong-Hong Kong-Macao Greater Bay Area has formed a biomedical industry city cluster in the Greater Bay Area with Guangzhou and Shenzhen as the core, and the coordinated development of cities such as Zhuhai, Foshan and Zhongshan.
    The dual-core drive drives the rapid improvement of the biomedical industry in the Greater Bay Area.
    Biomedical industry cities such as Shenzhen, Guangzhou, Zhuhai, Foshan, Zhongshan, Hong Kong, and Macau gather most of the listed companies and high-quality innovative resources in the Greater Bay Area , contributing to major industries.
    Scale and innovation results.
    It also has a number of key biomedical industry clusters such as Guangzhou Science City Bio-industry Base, Shenzhen National Bio-industry Base, Zhongshan Torch High-tech Industrial Development Zone, Hong Kong Science Park, Guangdong-Macao Cooperation Traditional Chinese Medicine Technology Industrial Park.
     
      Figure 1: As of December 31, 2020, the number of listed biopharmaceutical companies in 9 cities in the Guangdong-Hong Kong-Macao Greater Bay Area (units)
      Data source: Flint Creation Database
     
      Figure 2: As of 2020, the number of drug clinical trials in 9 cities in the Guangdong-Hong Kong-Macao Greater Bay Area and the cumulative number of new drugs accepted by CDE for Class I and II (pieces)
      Data source: Flint Creation Database
     
      In the context of the integration of the Guangdong-Hong Kong-Macao Greater Bay Area, strengthen the regional industrial innovation layout and promote the coordinated development of industries.
    According to the "Recommendation of the CPC Guangdong Provincial Committee on Formulating the Fourteenth Five-Year Plan for the National Economic and Social Development of Guangdong Province and the Long-term Goals for 2035", Guangdong Province will focus on building biomedicine and biomedicine products during the "14th Five-Year Plan" period.
    Ten strategic pillar industry clusters represented by the health industry, and together with Hong Kong and Macao to build an international scientific and technological innovation center with global influence.
    At the same time, according to the "Notice on Several Policies and Measures to Promote the Innovation and Development of Biomedicine" issued by nine departments including the Guangdong Provincial Department of Science and Technology, Guangdong Province will focus on Guangzhou and Shenzhen as the core in the future to create a rational layout, dislocation development, and coordinated linkage.
    , Guangshen Hong Kong, GuangZhuMacao Biomedical Technology Innovation Concentration Zone where resources are concentrated.
    Among them, Guangzhou will build the Guangdong-Hong Kong-Macao Greater Bay Area life science cooperation zone and biomedical research and development center; Shenzhen will focus on cultivating world-standard biomedical companies and research institutions to create a global biomedical innovation and development source; Zhuhai, Foshan, and Zhongshan will build biomedical New medical resource allocation center, biomedical science and technology achievement transformation base, and biomedical science and technology international cooperation innovation zone; Huizhou and Dongguan will build important domestic nuclear medicine R&D centers and biomedicine R&D and manufacturing bases; Jiangmen and Zhaoqing will build large animal experiments for regenerative medicine Base, Nanyao health industry base; Eastern Guangdong, Western Guangdong, Northern Guangdong, construction of chemical raw material medicine production base, authentic medicinal materials and Lingnan characteristic Chinese medicinal material raw material industrial base.
    In addition, Hong Kong relies on the Hong Kong Science Park to promote the transformation of high-value biomedical research.
    Macau focuses on the inheritance and development of characteristic Chinese medicines.
     
      Figure 3: The layout of the biomedical industry in 9+2 cities in the Guangdong-Hong Kong-Macao Greater Bay Area
      Image source: Flint Creation
     
      2.
    Collaborative innovation of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area
     
      Development experience
     
      1.
    Establish an industrial development leading group to coordinate cross-regional industrial cooperation
     
      On the basis of the Guangdong Provincial Leading Group for the Implementation of the "Outline of the Reform and Development Plan for the Pearl River Delta Region (2008-2020)" and the Provincial Leading Group for Promoting the Rejuvenation and Development of the Eastern, Western and Northern Regions of Guangdong, Guangdong integrated the establishment of the Provincial Leading Group for Regional Coordinated Development to coordinate and coordinate Study and solve major problems in the coordinated development of the province’s regions.
    In addition, Guangzhou actively promotes the Biomedicine and Health Industry Special Team Office of the Guangdong-Hong Kong-Macao Greater Bay Area Construction Leading Group (located in the Municipal Development and Reform Commission) under the leadership of the municipal government to coordinate the organization and arrangement of various fund projects, and each business leader According to their responsibilities, the division of labor unions and the Municipal Finance Bureau shall prepare annual capital budgets, and organize project declaration, review and confirmation, and management supervision by item.
     
      2.
    Highlight the synergy and cooperation in key and characteristic industries and enhance the ability to integrate resources
     
      Focus on promoting the integration of traditional Chinese medicine resources in Guangdong, Hong Kong and Macao.
    Relying on the basic advantages of the Guangdong-Hong Kong-Macao Greater Bay Area in terms of concentration of Chinese medicine disciplines and talents, and high level of talent training and scientific research, in December 2019, the competent government departments of Guangdong, Hong Kong and Macao jointly signed the "Guangdong-Hong Kong-Macao Greater Bay Area TCM Cooperation Memorandum" Establish a regular consultation mechanism between the competent government departments of Guangdong, Hong Kong and Macao, support Hong Kong and Macao TCM medical institutions to join the Pearl River Delta medical system, build a medical alliance in the Greater Bay Area, build a Guangdong-Hong Kong-Macao Greater Bay Area TCM innovation platform, and promote the focus of traditional Chinese medicine in Guangdong, Hong Kong and Macau.
    Sharing resources of laboratories and scientific research institutions, expanding cooperation in the field of Chinese medicine and health, building a Guangdong, Hong Kong and Macao Chinese medicine cultural heritage and dissemination center, and promoting the implementation of Hong Kong and Macao Chinese medicine medical institutions and Chinese medicine doctor admission policies.
     
      3.
    Cooperate to build the park carrier and build an open international cooperation platform
     
      Guangdong-Macao Cooperation Traditional Chinese Medicine Technology Industrial Park.
    In April 2011, as the first landing project of the "Guangdong-Macao Cooperation Framework Agreement", the Guangdong-Macao Cooperation Traditional Chinese Medicine Technology Industrial Park landed in Hengqin.
    The industrial park is jointly established by Macau and Hengqin to conduct development, construction, operation and management.
    The overall positioning is to create an "international window for the traditional Chinese medicine industry and culture along the way.
    " At present, the park has set up a professional public service platform with international advanced standards and an integrated whole chain of GMP pilot production, R&D and testing, and industrial incubation bases in Mainland China and EU certification standards.
    It plays an important role in building a business docking model and market network connecting ASEAN, Africa, and the European Union.
    It has become one of the important carriers to promote the moderately diversified economic development of Macao and integrate into the overall development of the country.
     
      Hong Kong-Shenzhen Innovation and Technology Park.
    In January 2017, Shenzhen and Hong Kong formally signed the "Memorandum of Cooperation on Promoting the Common Development of the Lok Ma Chau Loop between Hong Kong and Shenzhen", cooperating in the development of the Loop area as the "Hong Kong-Shenzhen Innovation and Technology Park", establishing key scientific research cooperation bases, and planning to establish offshore innovation Base, explore and implement the policy of facilitating the flow of scientific research materials and the special supervision policy of medicines and medical devices.
    Shenzhen and Hong Kong complement each other's advantages and jointly build a "Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone" with agglomeration and synergy effects.
     
      4.
    Strengthen policy coordination and promote the cross-regional flow of high-quality innovative elements
     
      In terms of supervision and review and approval, in December 2020, eight departments including the State Administration for Market Regulation, the State Food and Drug Administration, and the National Development and Reform Commission jointly issued the "Guangdong-Hong Kong-Macao Greater Bay Area Pharmaceutical and Medical Device Regulatory Innovation and Development Work Plan" to promote the Greater Bay Area Innovative development of pharmaceutical and medical device supervision, exploring the establishment of a new interactive and mutually beneficial pharmaceutical and medical device cooperation model, and improving the supervision system.
    At the same time, the Greater Bay Area Center for Drug Evaluation and Inspection of the National Medical Products Administration and the Greater Bay Area Center for Medical Device Technology Evaluation and Inspection were established in Futian, Shenzhen to further deepen the reform of the review and approval system, and strengthen the supervision of drugs and medical devices in the Guangdong-Hong Kong-Macao Greater Bay Area.
    Promote the transformation of pharmaceutical and medical device achievements, optimize the business environment, and promote the clustering and innovative development of industries.
     
      In terms of talent introduction support, in 2019, the “Notice of the State Administration of Taxation of the Ministry of Finance on the Preferential Policies for Individual Income Tax in the Guangdong-Hong Kong-Macao Greater Bay Area” proposed that the nine Pearl River Delta cities in the Guangdong-Hong Kong-Macao Greater Bay Area will follow the difference in individual income tax burden between the Mainland and Hong Kong.
    Overseas (including Hong Kong, Macau, and Taiwan) high-end talents and talents in short supply working in the Greater Bay Area will be subsidized, and the subsidy will be exempt from personal income tax.
     
      In terms of mutual recognition of intellectual property rights, the “10 Articles of Mutual Recognition of Intellectual Property Rights between Guangdong, Hong Kong and Macao” was issued in 2019, covering intellectual property services, arbitration and mediation, rights protection cooperation, IP financial supermarkets, guarantees, financial leasing, securities financing, industry interaction, and equivalent In terms of identification and other aspects, promote the mutual recognition of intellectual property rights among Guangdong, Hong Kong and Macao, covering all areas of intellectual property creation, protection, use, service and management.
     
      5.
    Deepen the collaboration of industry, university, research and medical, and innovate the cooperative organization model
     
      Collaboration between universities and scientific research institutions.
    In recent years, Shenzhen and Hong Kong have cooperated to establish scientific research institutions such as the Chinese University of Hong Kong (Shenzhen), Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen Research Institute of City University of Hong Kong, Shenzhen Research Institute of Hong Kong Polytechnic University, Shenzhen Peking University and Hong Kong University of Science and Technology Medical Center.
    , To carry out in-depth research and cooperation in medical fields such as biomedicine, biomedical materials, traditional Chinese medicine, molecular diagnosis, brain science, and structural biology .
     
      Cooperation with medical institutions.
    The "Outline of the Development Plan for the Guangdong-Hong Kong-Macao Greater Bay Area" proposes to promote close cooperation with high-quality medical and health resources, and support Hong Kong and Macao medical and health service providers to set up medical institutions in the nine cities of the Pearl River Delta in the form of sole proprietorship, joint venture or cooperation in accordance with regulations.
    Medical institutions have created loose conditions.
    For example, Shenzhen has the University of Hong Kong Shenzhen Hospital, Hong Kong Famous Doctors Clinic, Shenzhen Ximalin Shunchao Eye Hospital, Shenzhen Sili Medical Beauty Clinic, Shenzhen Futian Zhihao Comprehensive Clinic, Shenzhen Zhu Shengji Dental Clinic, Shenzhen Gangquan Comprehensive Clinic, etc.
    Many Hong Kong-owned medical institutions have settled down.
     
      Cooperation in scientific research and clinical teaching.
    Zhongshan and Macau, Shenzhen Pingshan District Heshuntang Medicine and Macau University of Science and Technology, Hong Kong University and Guangdong Pharmaceutical University jointly established a platform for talent exchange and laboratory research and development cooperation; Shenzhen People’s Hospital cooperated with the University of Hong Kong and the Chinese University of Hong Kong to develop Guangdong Hong Kong's innovative scientific research project cooperation; Shenzhen Hospital of Guangzhou University of Chinese Medicine has established clinical teaching cooperation with universities such as the Chinese University of Hong Kong School of Chinese Medicine and the School of Professional and Continuing Education of the University of Hong Kong.
     
      Industry promotes cooperation.
    Establish the Foshan Chan-Shen Modern Industrial Cooperation Promotion Association and the Shenzhen-Foshan Industry Development Promotion Alliance to create a new dual-city cooperation model of "Shenzhen Innovation + Foshan Manufacturing", jointly build a Chan-Shen dual-city industrial innovation cooperation center, and build a government-coordinated, association The modern association innovation ecological chain with the three major contents of link and enterprise service provides in-depth services such as industry-university-research services, financial services, corporate services, urban pharmnet.
    com.
    cn/" target="_blank">investment services, industrial innovation services, and high-end resource docking for the integrated development of industries in Shenzhen and Foshan.
    Value-sharing economic zone between the two places of Buddha.
     
      6.
    Promote the construction of major scientific research and service platforms to enhance comprehensive service capabilities
     
      In terms of key laboratories, promote the construction of the Guangdong-Hong Kong-Macao Greater Bay Area Biosafety Innovation Research Institute and Nano Biosafety Center.
    Initiate the construction of the South China Biosafety Laboratory System and lay out the construction of high-level biosafety laboratories to provide service guarantees for public health safety in the Guangdong-Hong Kong-Macao Greater Bay Area.
    In terms of inspection institutions, promote the construction of a quality evaluation system for the entire TCM industry chain and an authoritative research institution for the international standards of TCM in the Guangdong-Hong Kong-Macao Greater Bay Area, accelerate the construction of a drug safety evaluation center with full-capacity GLP laboratories and high-level biosafety laboratories, and improve the Medical device inspection and testing capabilities; in terms of health and medical big data centers, it realizes the sharing and exchange of health and medical data, cross-regional aggregation and scientific utilization; in terms of research platforms, promotes Southern University of Science and Technology, Shenzhen University and other Hong Kong research institutions to carry out cutting-edge scientific and technological cooperation, focusing on innovation In the fields of drug R&D and clinical research, the Shenzhen-Hong Kong Institute of Biomedicine Innovation and other platforms will be built in the Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone to enhance the basic research capabilities of biomedicine; in terms of the achievement transformation platform, the Hong Kong Polytechnic University, the University of Hong Kong and other international scientific research institutions will be built The Shenzhen-Hong Kong Clinical Translation Center conducts clinical translational research on new technologies for diagnosis and treatment.
     
      In general, the key biomedicine cities in the Guangdong-Hong Kong-Macao Greater Bay Area have implemented the "Guangdong-Hong Kong-Macao Greater Bay Area Development Plan Outline", mainly through the optimization of industrial innovation layout, deepening cooperation in characteristic industries, and promoting the joint construction of park carriers.
    Promote the flow of innovative resource elements, deepen the collaborative cooperation between industry, university, research and medical, and promote the construction of major scientific research and service platforms to comprehensively promote the collaborative innovation of the biomedical industry in the Bay Area.
    Facing the future, for the high-quality, integrated and international development of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area, it is also necessary to break the administrative barriers of the Bay Area, improve policy coordination, give play to the comparative advantages of various regions, and realize a rational division of labor in the region, focusing on industrial governance and resources.
    Integrate as a starting point to comprehensively improve governance efficiency, the innovative synergy of specialized clusters, and the comprehensive capabilities of innovative services, and further strengthen Hong Kong’s role as a “super contact” for innovation and technology, seize opportunities for the Belt and Road development, accelerate international cooperation, and enhance global competitiveness And influence.
      The Guangdong-Hong Kong-Macao Greater Bay Area is an important area where my country’s biomedical industry gathers.
    It has a complete industrial foundation and leading strength.
    With the development of the Guangdong-Hong Kong-Macao Greater Bay Area and many other national strategies, the development of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area is entering a new stage of integrated and coordinated development.
    In this article, the author mainly starts from the perspective of regional collaborative innovation, focusing on analyzing the development pattern of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area, and summarizing the regional industrial collaborative innovation development experience, in order to provide reference for local governments, parks and industrial investors.
     
      1.
    The development pattern of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area
     
      A development pattern driven by Guangzhou and Shenzhen, supported by Hong Kong, Macau, Zhuhai, Foshan, and Zhongshan, and supported by Dongguan, Huizhou, Jiangmen, and Zhaoqing, has taken shape, with a sound industrial foundation.
    In recent years, the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area has been advancing in depth in a new round of regional waves centered on the layout of innovative resources.
    The scale of the industry has continued to grow, the industrial system has become more and more perfect, the industrial strength is leading the country, and the agglomeration effect has become increasingly international.
    The degree continues to increase.
    At present, the Guangdong-Hong Kong-Macao Greater Bay Area has formed a biomedical industry city cluster in the Greater Bay Area with Guangzhou and Shenzhen as the core, and the coordinated development of cities such as Zhuhai, Foshan and Zhongshan.
    The dual-core drive drives the rapid improvement of the biomedical industry in the Greater Bay Area.
    Biomedical industry cities such as Shenzhen, Guangzhou, Zhuhai, Foshan, Zhongshan, Hong Kong, and Macau gather most of the listed companies and high-quality innovative resources in the Greater Bay Area , contributing to major industries.
    Scale and innovation results.
    It also has a number of key biomedical industry clusters such as Guangzhou Science City Bio-industry Base, Shenzhen National Bio-industry Base, Zhongshan Torch High-tech Industrial Development Zone, Hong Kong Science Park, Guangdong-Macao Cooperation Traditional Chinese Medicine Technology Industrial Park.
     
      Figure 1: As of December 31, 2020, the number of listed biopharmaceutical companies in 9 cities in the Guangdong-Hong Kong-Macao Greater Bay Area (units)
      Data source: Flint Creation Database
     
      Figure 2: As of 2020, the number of drug clinical trials in 9 cities in the Guangdong-Hong Kong-Macao Greater Bay Area and the cumulative number of new drugs accepted by CDE for Class I and II (pieces)
      Data source: Flint Creation Database
     
      In the context of the integration of the Guangdong-Hong Kong-Macao Greater Bay Area, strengthen the regional industrial innovation layout and promote the coordinated development of industries.
    According to the "Recommendation of the CPC Guangdong Provincial Committee on Formulating the Fourteenth Five-Year Plan for the National Economic and Social Development of Guangdong Province and the Long-term Goals for 2035", Guangdong Province will focus on building biomedicine and biomedicine products during the "14th Five-Year Plan" period.
    Ten strategic pillar industry clusters represented by the health industry, and together with Hong Kong and Macao to build an international scientific and technological innovation center with global influence.
    At the same time, according to the "Notice on Several Policies and Measures to Promote the Innovation and Development of Biomedicine" issued by nine departments including the Guangdong Provincial Department of Science and Technology, Guangdong Province will focus on Guangzhou and Shenzhen as the core in the future to create a rational layout, dislocation development, and coordinated linkage.
    , Guangshen Hong Kong, GuangZhuMacao Biomedical Technology Innovation Concentration Zone where resources are concentrated.
    Among them, Guangzhou will build the Guangdong-Hong Kong-Macao Greater Bay Area life science cooperation zone and biomedical research and development center; Shenzhen will focus on cultivating world-standard biomedical companies and research institutions to create a global biomedical innovation and development source; Zhuhai, Foshan, and Zhongshan will build biomedical New medical resource allocation center, biomedical science and technology achievement transformation base, and biomedical science and technology international cooperation innovation zone; Huizhou and Dongguan will build important domestic nuclear medicine R&D centers and biomedicine R&D and manufacturing bases; Jiangmen and Zhaoqing will build large animal experiments for regenerative medicine Base, Nanyao health industry base; Eastern Guangdong, Western Guangdong, Northern Guangdong, construction of chemical raw material medicine production base, authentic medicinal materials and Lingnan characteristic Chinese medicinal material raw material industrial base.
    In addition, Hong Kong relies on the Hong Kong Science Park to promote the transformation of high-value biomedical research.
    Macau focuses on the inheritance and development of characteristic Chinese medicines.
     
      Figure 3: The layout of the biomedical industry in 9+2 cities in the Guangdong-Hong Kong-Macao Greater Bay Area
      Image source: Flint Creation
     
      2.
    Collaborative innovation of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area
     
      Development experience
     
      1.
    Establish an industrial development leading group to coordinate cross-regional industrial cooperation
     
      On the basis of the Guangdong Provincial Leading Group for the Implementation of the "Outline of the Reform and Development Plan for the Pearl River Delta Region (2008-2020)" and the Provincial Leading Group for Promoting the Rejuvenation and Development of the Eastern, Western and Northern Regions of Guangdong, Guangdong integrated the establishment of the Provincial Leading Group for Regional Coordinated Development to coordinate and coordinate Study and solve major problems in the coordinated development of the province’s regions.
    In addition, Guangzhou actively promotes the Biomedicine and Health Industry Special Team Office of the Guangdong-Hong Kong-Macao Greater Bay Area Construction Leading Group (located in the Municipal Development and Reform Commission) under the leadership of the municipal government to coordinate the organization and arrangement of various fund projects, and each business leader According to their responsibilities, the division of labor unions and the Municipal Finance Bureau shall prepare annual capital budgets, and organize project declaration, review and confirmation, and management supervision by item.
     
      2.
    Highlight the synergy and cooperation in key and characteristic industries and enhance the ability to integrate resources
     
      Focus on promoting the integration of traditional Chinese medicine resources in Guangdong, Hong Kong and Macao.
    Relying on the basic advantages of the Guangdong-Hong Kong-Macao Greater Bay Area in terms of concentration of Chinese medicine disciplines and talents, and high level of talent training and scientific research, in December 2019, the competent government departments of Guangdong, Hong Kong and Macao jointly signed the "Guangdong-Hong Kong-Macao Greater Bay Area TCM Cooperation Memorandum" Establish a regular consultation mechanism between the competent government departments of Guangdong, Hong Kong and Macao, support Hong Kong and Macao TCM medical institutions to join the Pearl River Delta medical system, build a medical alliance in the Greater Bay Area, build a Guangdong-Hong Kong-Macao Greater Bay Area TCM innovation platform, and promote the focus of traditional Chinese medicine in Guangdong, Hong Kong and Macau.
    Sharing resources of laboratories and scientific research institutions, expanding cooperation in the field of Chinese medicine and health, building a Guangdong, Hong Kong and Macao Chinese medicine cultural heritage and dissemination center, and promoting the implementation of Hong Kong and Macao Chinese medicine medical institutions and Chinese medicine doctor admission policies.
     
      3.
    Cooperate to build the park carrier and build an open international cooperation platform
     
      Guangdong-Macao Cooperation Traditional Chinese Medicine Technology Industrial Park.
    In April 2011, as the first landing project of the "Guangdong-Macao Cooperation Framework Agreement", the Guangdong-Macao Cooperation Traditional Chinese Medicine Technology Industrial Park landed in Hengqin.
    The industrial park is jointly established by Macau and Hengqin to conduct development, construction, operation and management.
    The overall positioning is to create an "international window for the traditional Chinese medicine industry and culture along the way.
    " At present, the park has set up a professional public service platform with international advanced standards and an integrated whole chain of GMP pilot production, R&D and testing, and industrial incubation bases in Mainland China and EU certification standards.
    It plays an important role in building a business docking model and market network connecting ASEAN, Africa, and the European Union.
    It has become one of the important carriers to promote the moderately diversified economic development of Macao and integrate into the overall development of the country.
     
      Hong Kong-Shenzhen Innovation and Technology Park.
    In January 2017, Shenzhen and Hong Kong formally signed the "Memorandum of Cooperation on Promoting the Common Development of the Lok Ma Chau Loop between Hong Kong and Shenzhen", cooperating in the development of the Loop area as the "Hong Kong-Shenzhen Innovation and Technology Park", establishing key scientific research cooperation bases, and planning to establish offshore innovation Base, explore and implement the policy of facilitating the flow of scientific research materials and the special supervision policy of medicines and medical devices.
    Shenzhen and Hong Kong complement each other's advantages and jointly build a "Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone" with agglomeration and synergy effects.
     
      4.
    Strengthen policy coordination and promote the cross-regional flow of high-quality innovative elements
     
      In terms of supervision and review and approval, in December 2020, eight departments including the State Administration for Market Regulation, the State Food and Drug Administration, and the National Development and Reform Commission jointly issued the "Guangdong-Hong Kong-Macao Greater Bay Area Pharmaceutical and Medical Device Regulatory Innovation and Development Work Plan" to promote the Greater Bay Area Innovative development of pharmaceutical and medical device supervision, exploring the establishment of a new interactive and mutually beneficial pharmaceutical and medical device cooperation model, and improving the supervision system.
    At the same time, the Greater Bay Area Center for Drug Evaluation and Inspection of the National Medical Products Administration and the Greater Bay Area Center for Medical Device Technology Evaluation and Inspection were established in Futian, Shenzhen to further deepen the reform of the review and approval system, and strengthen the supervision of drugs and medical devices in the Guangdong-Hong Kong-Macao Greater Bay Area.
    Promote the transformation of pharmaceutical and medical device achievements, optimize the business environment, and promote the clustering and innovative development of industries.
     
      In terms of talent introduction support, in 2019, the “Notice of the State Administration of Taxation of the Ministry of Finance on the Preferential Policies for Individual Income Tax in the Guangdong-Hong Kong-Macao Greater Bay Area” proposed that the nine Pearl River Delta cities in the Guangdong-Hong Kong-Macao Greater Bay Area will follow the difference in individual income tax burden between the Mainland and Hong Kong.
    Overseas (including Hong Kong, Macau, and Taiwan) high-end talents and talents in short supply working in the Greater Bay Area will be subsidized, and the subsidy will be exempt from personal income tax.
     
      In terms of mutual recognition of intellectual property rights, the “10 Articles of Mutual Recognition of Intellectual Property Rights between Guangdong, Hong Kong and Macao” was issued in 2019, covering intellectual property services, arbitration and mediation, rights protection cooperation, IP financial supermarkets, guarantees, financial leasing, securities financing, industry interaction, and equivalent In terms of identification and other aspects, promote the mutual recognition of intellectual property rights among Guangdong, Hong Kong and Macao, covering all areas of intellectual property creation, protection, use, service and management.
     
      5.
    Deepen the collaboration of industry, university, research and medical, and innovate the cooperative organization model
     
      Collaboration between universities and scientific research institutions.
    In recent years, Shenzhen and Hong Kong have cooperated to establish scientific research institutions such as the Chinese University of Hong Kong (Shenzhen), Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen Research Institute of City University of Hong Kong, Shenzhen Research Institute of Hong Kong Polytechnic University, Shenzhen Peking University and Hong Kong University of Science and Technology Medical Center.
    , To carry out in-depth research and cooperation in medical fields such as biomedicine, biomedical materials, traditional Chinese medicine, molecular diagnosis, brain science, and structural biology .
     
      Cooperation with medical institutions.
    The "Outline of the Development Plan for the Guangdong-Hong Kong-Macao Greater Bay Area" proposes to promote close cooperation with high-quality medical and health resources, and support Hong Kong and Macao medical and health service providers to set up medical institutions in the nine cities of the Pearl River Delta in the form of sole proprietorship, joint venture or cooperation in accordance with regulations.
    Medical institutions have created loose conditions.
    For example, Shenzhen has the University of Hong Kong Shenzhen Hospital, Hong Kong Famous Doctors Clinic, Shenzhen Ximalin Shunchao Eye Hospital, Shenzhen Sili Medical Beauty Clinic, Shenzhen Futian Zhihao Comprehensive Clinic, Shenzhen Zhu Shengji Dental Clinic, Shenzhen Gangquan Comprehensive Clinic, etc.
    Many Hong Kong-owned medical institutions have settled down.
     
      Cooperation in scientific research and clinical teaching.
    Zhongshan and Macau, Shenzhen Pingshan District Heshuntang Medicine and Macau University of Science and Technology, Hong Kong University and Guangdong Pharmaceutical University jointly established a platform for talent exchange and laboratory research and development cooperation; Shenzhen People’s Hospital cooperated with the University of Hong Kong and the Chinese University of Hong Kong to develop Guangdong Hong Kong's innovative scientific research project cooperation; Shenzhen Hospital of Guangzhou University of Chinese Medicine has established clinical teaching cooperation with universities such as the Chinese University of Hong Kong School of Chinese Medicine and the School of Professional and Continuing Education of the University of Hong Kong.
     
      Industry promotes cooperation.
    Establish the Foshan Chan-Shen Modern Industrial Cooperation Promotion Association and the Shenzhen-Foshan Industry Development Promotion Alliance to create a new dual-city cooperation model of "Shenzhen Innovation + Foshan Manufacturing", jointly build a Chan-Shen dual-city industrial innovation cooperation center, and build a government-coordinated, association The modern association innovation ecological chain with the three major contents of link and enterprise service provides in-depth services such as industry-university-research services, financial services, corporate services, urban pharmnet.
    com.
    cn/" target="_blank">investment services, industrial innovation services, and high-end resource docking for the integrated development of industries in Shenzhen and Foshan.
    Value-sharing economic zone between the two places of Buddha.
     
      6.
    Promote the construction of major scientific research and service platforms to enhance comprehensive service capabilities
     
      In terms of key laboratories, promote the construction of the Guangdong-Hong Kong-Macao Greater Bay Area Biosafety Innovation Research Institute and Nano Biosafety Center.
    Initiate the construction of the South China Biosafety Laboratory System and lay out the construction of high-level biosafety laboratories to provide service guarantees for public health safety in the Guangdong-Hong Kong-Macao Greater Bay Area.
    In terms of inspection institutions, promote the construction of a quality evaluation system for the entire TCM industry chain and an authoritative research institution for the international standards of TCM in the Guangdong-Hong Kong-Macao Greater Bay Area, accelerate the construction of a drug safety evaluation center with full-capacity GLP laboratories and high-level biosafety laboratories, and improve the Medical device inspection and testing capabilities; in terms of health and medical big data centers, it realizes the sharing and exchange of health and medical data, cross-regional aggregation and scientific utilization; in terms of research platforms, promotes Southern University of Science and Technology, Shenzhen University and other Hong Kong research institutions to carry out cutting-edge scientific and technological cooperation, focusing on innovation In the fields of drug R&D and clinical research, the Shenzhen-Hong Kong Institute of Biomedicine Innovation and other platforms will be built in the Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone to enhance the basic research capabilities of biomedicine; in terms of the achievement transformation platform, the Hong Kong Polytechnic University, the University of Hong Kong and other international scientific research institutions will be built The Shenzhen-Hong Kong Clinical Translation Center conducts clinical translational research on new technologies for diagnosis and treatment.
     
      In general, the key biomedicine cities in the Guangdong-Hong Kong-Macao Greater Bay Area have implemented the "Guangdong-Hong Kong-Macao Greater Bay Area Development Plan Outline", mainly through the optimization of industrial innovation layout, deepening cooperation in characteristic industries, and promoting the joint construction of park carriers.
    Promote the flow of innovative resource elements, deepen the collaborative cooperation between industry, university, research and medical, and promote the construction of major scientific research and service platforms to comprehensively promote the collaborative innovation of the biomedical industry in the Bay Area.
    Facing the future, for the high-quality, integrated and international development of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area, it is also necessary to break the administrative barriers of the Bay Area, improve policy coordination, give play to the comparative advantages of various regions, and realize a rational division of labor in the region, focusing on industrial governance and resources.
    Integrate as a starting point to comprehensively improve governance efficiency, the innovative synergy of specialized clusters, and the comprehensive capabilities of innovative services, and further strengthen Hong Kong’s role as a “super contact” for innovation and technology, seize opportunities for the Belt and Road development, accelerate international cooperation, and enhance global competitiveness And influence.
      The Guangdong-Hong Kong-Macao Greater Bay Area is an important area where my country’s biomedical industry gathers.
    It has a complete industrial foundation and leading strength.
    With the development of the Guangdong-Hong Kong-Macao Greater Bay Area and many other national strategies, the development of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area is entering a new stage of integrated and coordinated development.
    In this article, the author mainly starts from the perspective of regional collaborative innovation, focusing on analyzing the development pattern of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area, and summarizing the regional industrial collaborative innovation development experience, in order to provide reference for local governments, parks and industrial investors.
     
      1.
    The development pattern of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area
      1.
    The development pattern of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area
     
      A development pattern driven by Guangzhou and Shenzhen, supported by Hong Kong, Macau, Zhuhai, Foshan, and Zhongshan, and supported by Dongguan, Huizhou, Jiangmen, and Zhaoqing, has taken shape, with a sound industrial foundation.
    In recent years, the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area has been advancing in depth in a new round of regional waves centered on the layout of innovative resources.
    The scale of the industry has continued to grow, the industrial system has become more and more perfect, the industrial strength is leading the country, and the agglomeration effect has become increasingly international.
    The degree continues to increase.
    At present, the Guangdong-Hong Kong-Macao Greater Bay Area has formed a biomedical industry city cluster in the Greater Bay Area with Guangzhou and Shenzhen as the core, and the coordinated development of cities such as Zhuhai, Foshan and Zhongshan.
    The dual-core drive drives the rapid improvement of the biomedical industry in the Greater Bay Area.
    Biomedical industry cities such as Shenzhen, Guangzhou, Zhuhai, Foshan, Zhongshan, Hong Kong, and Macau gather most of the listed companies and high-quality innovative resources in the Greater Bay Area , contributing to major industries.
    Scale and innovation results.
    It also has a number of key biomedical industry clusters such as Guangzhou Science City Bio-industry Base, Shenzhen National Bio-industry Base, Zhongshan Torch High-tech Industrial Development Zone, Hong Kong Science Park, Guangdong-Macao Cooperation Traditional Chinese Medicine Technology Industrial Park.
    Enterprise business enterprise
     
      Figure 1: As of December 31, 2020, the number of listed biopharmaceutical companies in 9 cities in the Guangdong-Hong Kong-Macao Greater Bay Area (units)
      Data source: Flint Creation Database
     
      Figure 2: As of 2020, the number of drug clinical trials in 9 cities in the Guangdong-Hong Kong-Macao Greater Bay Area and the cumulative number of new drugs accepted by CDE for Class I and II (pieces)
      Data source: Flint Creation Database
     
      In the context of the integration of the Guangdong-Hong Kong-Macao Greater Bay Area, strengthen the regional industrial innovation layout and promote the coordinated development of industries.
    According to the "Recommendation of the CPC Guangdong Provincial Committee on Formulating the Fourteenth Five-Year Plan for the National Economic and Social Development of Guangdong Province and the Long-term Goals for 2035", Guangdong Province will focus on building biomedicine and biomedicine products during the "14th Five-Year Plan" period.
    Ten strategic pillar industry clusters represented by the health industry, and together with Hong Kong and Macao to build an international scientific and technological innovation center with global influence.
    At the same time, according to the "Notice on Several Policies and Measures to Promote the Innovation and Development of Biomedicine" issued by nine departments including the Guangdong Provincial Department of Science and Technology, Guangdong Province will focus on Guangzhou and Shenzhen as the core in the future to create a rational layout, dislocation development, and coordinated linkage.
    , Guangshen Hong Kong, GuangZhuMacao Biomedical Technology Innovation Concentration Zone where resources are concentrated.
    Among them, Guangzhou will build the Guangdong-Hong Kong-Macao Greater Bay Area life science cooperation zone and biomedical research and development center; Shenzhen will focus on cultivating world-standard biomedical companies and research institutions to create a global biomedical innovation and development source; Zhuhai, Foshan, and Zhongshan will build biomedical New medical resource allocation center, biomedical science and technology achievement transformation base, and biomedical science and technology international cooperation innovation zone; Huizhou and Dongguan will build important domestic nuclear medicine R&D centers and biomedicine R&D and manufacturing bases; Jiangmen and Zhaoqing will build large animal experiments for regenerative medicine Base, Nanyao health industry base; Eastern Guangdong, Western Guangdong, Northern Guangdong, construction of chemical raw material medicine production base, authentic medicinal materials and Lingnan characteristic Chinese medicinal material raw material industrial base.
    In addition, Hong Kong relies on the Hong Kong Science Park to promote the transformation of high-value biomedical research.
    Macau focuses on the inheritance and development of characteristic Chinese medicines.
     
      Figure 3: The layout of the biomedical industry in 9+2 cities in the Guangdong-Hong Kong-Macao Greater Bay Area
      Image source: Flint Creation
     
      2.
    Collaborative innovation of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area
      2.
    Collaborative innovation of the biomedical industry in the Guangdong-Hong Kong-Macao Greater Bay Area
     
      Development experience
      Development experience
     
      1.
    Establish an industrial development leading group to coordinate cross-regional industrial cooperation
     
      On the basis of the Guangdong Provincial Leading Group for the Implementation of the "Outline of the Reform and Development Plan for the Pearl River Delta Region (2008-2020)" and the Provincial Leading Group for Promoting the Rejuvenation and Development of the Eastern, Western and Northern Regions of Guangdong, Guangdong integrated the establishment of the Provincial Leading Group for Regional Coordinated Development to coordinate and coordinate Study and solve major problems in the coordinated development of the province’s regions.
    In addition, Guangzhou actively promotes the Biomedicine and Health Industry Special Team Office of the Guangdong-Hong Kong-Macao Greater Bay Area Construction Leading Group (located in the Municipal Development and Reform Commission) under the leadership of the municipal government to coordinate the organization and arrangement of various fund projects, and each business leader According to their responsibilities, the division of labor unions and the Municipal Finance Bureau shall prepare annual capital budgets, and organize project declaration, review and confirmation, and management supervision by item.
     
      2.
    Highlight the synergy and cooperation in key and characteristic industries and enhance the ability to integrate resources
     
      Focus on promoting the integration of traditional Chinese medicine resources in Guangdong, Hong Kong and Macao.
    Relying on the basic advantages of the Guangdong-Hong Kong-Macao Greater Bay Area in terms of concentration of Chinese medicine disciplines and talents, and high level of talent training and scientific research, in December 2019, the competent government departments of Guangdong, Hong Kong and Macao jointly signed the "Guangdong-Hong Kong-Macao Greater Bay Area TCM Cooperation Memorandum" Establish a regular consultation mechanism between the competent government departments of Guangdong, Hong Kong and Macao, support Hong Kong and Macao TCM medical institutions to join the Pearl River Delta medical system, build a medical alliance in the Greater Bay Area, build a Guangdong-Hong Kong-Macao Greater Bay Area TCM innovation platform, and promote the focus of traditional Chinese medicine in Guangdong, Hong Kong and Macau.
    Sharing resources of laboratories and scientific research institutions, expanding cooperation in the field of Chinese medicine and health, building a Guangdong, Hong Kong and Macao Chinese medicine cultural heritage and dissemination center, and promoting the implementation of Hong Kong and Macao Chinese medicine medical institutions and Chinese medicine doctor admission policies.
     
      3.
    Cooperate to build the park carrier and build an open international cooperation platform
     
      Guangdong-Macao Cooperation Traditional Chinese Medicine Technology Industrial Park.
    In April 2011, as the first landing project of the "Guangdong-Macao Cooperation Framework Agreement", the Guangdong-Macao Cooperation Traditional Chinese Medicine Technology Industrial Park landed in Hengqin.
    The industrial park is jointly established by Macau and Hengqin to conduct development, construction, operation and management.
    The overall positioning is to create an "international window for the traditional Chinese medicine industry and culture along the way.
    " At present, the park has set up a professional public service platform with international advanced standards and an integrated whole chain of GMP pilot production, R&D and testing, and industrial incubation bases in Mainland China and EU certification standards.
    It plays an important role in building a business docking model and market network connecting ASEAN, Africa, and the European Union.
    It has become one of the important carriers to promote the moderately diversified economic development of Macao and integrate into the overall development of the country.
     
      Hong Kong-Shenzhen Innovation and Technology Park.
    In January 2017, Shenzhen and Hong Kong formally signed the "Memorandum of Cooperation on Promoting the Common Development of the Lok Ma Chau Loop between Hong Kong and Shenzhen", cooperating in the development of the Loop area as the "Hong Kong-Shenzhen Innovation and Technology Park", establishing key scientific research cooperation bases, and planning to establish offshore innovation Base, explore and implement the policy of facilitating the flow of scientific research materials and the special supervision policy of medicines and medical devices.
    Shenzhen and Hong Kong complement each other's advantages and jointly build a "Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone" with agglomeration and synergy effects.
    Medicine, medicine, medicine
     
      4.
    Strengthen policy coordination and promote the cross-regional flow of high-quality innovative elements
     
      In terms of supervision and review and approval, in December 2020, eight departments including the State Administration for Market Regulation, the State Food and Drug Administration, and the National Development and Reform Commission jointly issued the "Guangdong-Hong Kong-Macao Greater Bay Area Pharmaceutical and Medical Device Regulatory Innovation and Development Work Plan" to promote the Greater Bay Area Innovative development of pharmaceutical and medical device supervision, exploring the establishment of a new interactive and mutually beneficial pharmaceutical and medical device cooperation model, and improving the supervision system.
    At the same time, the Greater Bay Area Center for Drug Evaluation and Inspection of the National Medical Products Administration and the Greater Bay Area Center for Medical Device Technology Evaluation and Inspection were established in Futian, Shenzhen to further deepen the reform of the review and approval system, and strengthen the supervision of drugs and medical devices in the Guangdong-Hong Kong-Macao Greater Bay Area.
    Promote the transformation of pharmaceutical and medical device achievements, optimize the business environment, and promote the clustering and innovative development of industries.
     
      In terms of talent introduction support, in 2019, the “Notice of the State Administration of Taxation of the Ministry of Finance on the Preferential Policies for Individual Income Tax in the Guangdong-Hong Kong-Macao Greater Bay Area” proposed that the nine Pearl River Delta cities in the Guangdong-Hong Kong-Macao Greater Bay Area will follow the difference in individual income tax burden between the Mainland and Hong Kong.
    Overseas (including Hong Kong, Macau, and Taiwan) high-end talents and talents in short supply working in the Greater Bay Area will be subsidized, and the subsidy will be exempt from personal income tax.
     
      In terms of mutual recognition of intellectual property rights, the “10 Articles of Mutual Recognition of Intellectual Property Rights between Guangdong, Hong Kong and Macao” was issued in 2019, covering intellectual property services, arbitration and mediation, rights protection cooperation, IP financial supermarkets, guarantees, financial leasing, securities financing, industry interaction, and equivalent In terms of identification and other aspects, promote the mutual recognition of intellectual property rights among Guangdong, Hong Kong and Macao, covering all areas of intellectual property creation, protection, use, service and management.
     
      5.
    Deepen the collaboration of industry, university, research and medical, and innovate the cooperative organization model
     
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