Research on the development of biomedical industry in Henan Province

Focusing on chemical medicine, traditional Chinese medicine, biological medicine and medical devices, Henan Province has formed a whole industrial chain system, and gathered a number of leading enterprises such as Tailong, Furen, Lingrui, Antu, Hualan, etc In 2019, Henan Province proposed to focus on four fields of modern biology and life health industry, such as biomedicine As one of the top ten emerging industries, Henan Province will accelerate the construction of an important middle and high-end R & D and production base of biomedicine in China 1、 Industrial scale in 2017, Henan Province issued the opinions of the general office of the people's Government of Henan Province on accelerating the cultivation and development of emerging industrial clusters (yzb [2017] No 41), which proposed to focus on the cultivation and development of 10 emerging manufacturing industrial clusters such as biomedicine, highlighting the development of chemical innovative drugs, modern Chinese medicine, biotechnology drugs and high-end medical devices, By 2020, the industrial scale will exceed 400 billion yuan and become an important biomedical industrial base in China At the end of 2018, Henan Province issued the action plan for the development of modern biology and life health industry in Henan Province (hereinafter referred to as the action plan), which proposed to focus on four major areas, including biomedicine, and accelerate the construction of an important biomedical middle and high-end R & D and production base in China At the beginning of 2019, Henan Province determined modern biology and life health industry as one of the 10 key emerging industries, striving to achieve an industrial scale of more than 400 billion yuan after 3-5 years of efforts According to the analysis report of Henan biomedical industry in the first quarter of 2018 published by Henan Pharmaceutical Industry Association, in the first quarter of 2018, the total output value of Henan biomedical industry above designated size was 69.1 billion yuan, up 12.6% year-on-year, 2.6% lower than last year, lagging behind Shanghai, Jiangsu, Shandong and Guangdong, ranking the fifth in China The profit of the province's pharmaceutical industry was 5.6 billion yuan, up 12.1% year on year, 5.5% lower than that of 2017, higher than that of the national biomedical industry According to the flint creation database, up to now, the biomedical industry in Henan Province has gathered more than 100000 industrial entities, which are distributed in various links of the industrial chain, such as planting, R & D, production, service and trade circulation, among which more than 2000 are production and R & D enterprises in the field of biomedical and medical devices Among them, there are 5 listed enterprises on the main board, more than 20 on the new third board and 1 on the growth enterprise board 2、 Industrial chain Henan Province focuses on chemical medicine, traditional Chinese medicine, biological medicine and medical equipment, forming a whole industrial chain system, and gathering a number of leading enterprises such as Tailong, Furen, Lingrui, Antu, Hualan, etc In the field of traditional Chinese medicine, relying on rich medical resources, Henan Province has vigorously built the origin of traditional Chinese medicine, among which 6 traditional Chinese medicine bases, Cornus officinalis, yam, Salvia miltiorrhiza, honeysuckle, Rehmannia glutinosa and Rabdosia rubescens, have passed the national GAP certification In the field of biological products, blood products, human immunoglobulins and vaccines have formed certain advantages In the field of medical devices, the fields of minimally invasive intervention, detection and diagnosis reagents and equipment, medical materials, infusion, physical therapy and rehabilitation equipment have developed rapidly Table 1 data sources of some key enterprises in Henan biomedical industry: Based on the public data, 3 The spatial chain of Henan biomedical industry has formed the industrial development pattern with Zhengzhou and Xinxiang biomedical base as the key agglomeration area and Luyi County, Nanyang, Neihuang and other characteristics as the support （1） Zhengzhou biomedical industry cluster Zhengzhou biomedical industry cluster has initially formed a spatial pattern of "one base, two parks" agglomeration development of airport Experimental Zone, Xinzheng City and high tech Zone 1 Airport experimental area As the first comprehensive pilot area of International Airport Economy in China, Zhengzhou National High tech biological industry base has listed the pilot area of the airport The biomedical industry is one of the 5 + 3 core industries of the port The core plate is located in the core area of Shuanghe Lake in the south of the pilot area, supported by Zhengzhou airport biomedical park At present, the pilot area of the airport has been initially formed with biomedical research and development The biological industry cluster, which is mainly based on production and basically complete with infrastructure, has settled in projects such as Baiqiao biology, Haien pharmaceutical, Youte biology, Zhongke stem cell and yueren medicine As an important support for the development of biomedical industry in the pilot area of the airport, Zhengzhou airport biomedical park is based on regional planning, guided by the needs of enterprise landing and growth, serves the industry and participates in the industry, forming three core competitiveness: specialized property and supporting, the whole process support system of Biomedical industry, and the full cycle financial support system of biomedical enterprises At the same time, aiming at the commanding point of the industry, the park has laid out four core industries: innovative drugs, cell technology, IVD / third-party testing and medical devices, and invested 750 million yuan to build an industrial support platform in line with FDA and nmpa standards - "new drug screening and testing platform, preclinical drug research animal house, small molecule CMC preparation production service platform, large molecule pilot test and large-scale production service platform Cell technology service platform "to provide full process innovation, R & D and production support for enterprises entering the park By setting up Vic system to develop market-oriented operation mode, gathering core elements such as capital, talent, technology and platform related to industrial development, building a fully market-oriented and sustainable "Government Enterprise Park" interest community, and building a domestic first-class biological industry base integrating R & D, incubation and production At present, it has settled in somersault, Hongyun Huaning, jiabaorenhe and other leading enterprises in various fields of biomedicine at home and abroad 2 Xinzheng At present, Xinzheng City takes Xingang industrial cluster as the main carrier of biomedical industry In 2018, it actively promotes the construction of modern biomedical industrial park in south area Relying on Suicheng pharmaceutical, Runhong pharmaceutical, Sino German Medical Industrial Park, Ruifu Medical Industrial Park and other enterprises, it focuses on the development of biopharmaceutical, chemical innovative medicine, modern Chinese medicine, medical equipment and other industries, and promotes the emergence of traditional pharmaceutical industry The transformation of bio medicine and health life industry 3 At present, the high tech Zone takes Zhengzhou biomedical industrial park as the main carrier of biomedical industry, focuses on supporting gene engineering drugs, biological products, modernization of traditional Chinese medicine, Agricultural Bioengineering, high-tech seed industry, medical devices, health products and other industries, and gathers a number of key enterprises Including the diagnostic reagent enterprises represented by Huamei biology, bosai biology and Lili biology, the modern Chinese medicine enterprises represented by zhulinzhongsheng, Zhongjing pharmaceutical and huanke pharmaceutical, the chemical pharmaceutical enterprises represented by heyida pharmaceutical, Ruikang pharmaceutical and Yonghe pharmaceutical, the biological product enterprises represented by Puxin biology, haixingbanghe and biochemical factory, the South China Medical power and Huasheng medical Medical equipment enterprises represented by therapeutical appliances and saiford electronics, and veterinary medicine enterprises represented by Rida pharmaceutical, Senlong veterinary medicine and Kemei veterinary medicine 4 In addition to other regions, other regions have formed a multi-point layout Zhongmou county relies on enterprises such as Furen Pharmaceutical Group, xidelung company, Yugang pharmaceutical, etc to develop fields of chemical innovative drugs, preparations, biopharmaceuticals, etc.; Xingyang city relies on enterprises such as Ruilong pharmaceutical, etc to develop fields of modern Chinese medicine; Dengfeng city relies on enterprises such as huibaoyuan and Zhongjing pharmaceutical, etc to develop fields of healthy products and Chinese medicine （2） Xinxiang biopharmaceutical industry cluster Xinxiang biopharmaceutical industry cluster has initially formed the situation that biotechnology enterprises gather and develop in high-tech zone and plain demonstration zone, chemical raw material medicine and preparation enterprises gather and develop in Xinxiang County, Huixian city and Economic Development Zone, and modern Chinese medicine enterprises gather and develop in Huixian county and Fengqiu Biotechnology industry cluster The hi tech Zone has formed a life science and biotechnology industry cluster focusing on Hualan biology, Tuoxin biochemistry, Haibin pharmaceutical industry, Hualong biology, Zoe Jinming, etc., among which Hualan biology has become the largest blood product manufacturer and the largest influenza vaccine production base in China, and it has been determined as a national innovative pilot enterprise by the Ministry of science and technology; the nucleoside and nucleotide series of Tuoxin biochemistry Co., Ltd The products rank first in the same industry in the world, and become the first batch of enterprises listed on the new third board in the city The large health industry area in the plain demonstration area develops industries such as medicine and medical device production and manufacturing At present, the municipal biological and new medicine professional park with a total planning area of 4.27 square kilometers has been started to be constructed, the Hualan biological research and development pilot base, the leading enterprise in the park, has been completed, 7 monoclonal antibody projects have been settled, and the new biomedical research institute and other projects are accelerating In June 2018, Beijing Yichuang Biotechnology Industry Research Institute officially settled in Xinxiang plain demonstration area The research institute plans to introduce 15-20 high-quality projects with high technology content and good development prospects into the area within 5 years, forming the innovation and leapfrog development of biology and new medicine industry, promoting the introduction of high-end talents and teams, the construction of core technology platform, the cooperation between industry, University and research, the implementation, transformation and industrialization of innovation projects To build a biomedical "Silicon Valley" in Henan Province and even the whole country Industrial cluster of chemical raw materials, preparations and traditional Chinese medicine Huixian City, with a planting area of 100000 mu of traditional Chinese medicine, is a base and regular annual exhibition of traditional Chinese medicine, and a demonstration base of standardized cultivation of Bupleurum in Henan Province We have settled in Baiquan pharmaceutical, Xinhui pharmaceutical, Changle pharmaceutical and other well-known pharmaceutical enterprises In the future, we will focus on the introduction of Chinese patent medicines, biopharmaceuticals, antibiotics, pharmaceutical intermediates and other sub industries （3） Other multi-point supporting industrial clusters chemical pharmaceutical industrial clusters Relying on key chemical pharmaceutical enterprises such as Furen pharmaceutical, Lepu pharmaceutical, Tianfang pharmaceutical, etc., Zhoukou, Shangqiu and other regions have gradually formed a chemical pharmaceutical industry cluster Traditional Chinese medicine industry cluster Based on Nanyang, Xinyang, Yuzhou, Tangyin and other places, relying on regional characteristics of traditional Chinese medicine resources, a cluster of traditional Chinese medicine industry has been formed, and a number of leading enterprises including Nanyang zhongjingwanxi pharmaceutical, Xinyang Lingrui pharmaceutical have been gathered 4、 Innovation chain analysis 1 Innovation platform Up to now, relying on Zhengzhou, Xinxiang and other key agglomeration areas, Henan Province has more than 200 key innovation platforms for biomedical industry, including nearly 150 Zhengzhou biomedical innovation platforms, including 2 national enterprise technology centers, 1 National Engineering Technology Research Center and 1 national and local joint engineering laboratory, 42 provincial and municipal enterprise technology centers, and 51 provincial and municipal enterprise technology centers Engineering Technology Research Center, and 58 provincial and municipal engineering laboratories (engineering research centers) Xinxiang City has 5 national R & D platforms and 35 provincial R & D platforms 2 According to the flint creation database, up to now, Henan Province has been approved 3366 domestic drugs, including 2283 chemical drugs, 97 biological products for treatment and 862 traditional Chinese medicines In total, 10633 domestic medical devices were approved, including 2696 class I medical devices, 7127 class II medical devices and 810 class III medical devices 3 According to Huoshi creation database, innovation capital shows that up to now, there have been 55 m & A events and 10 financing events in Henan bio pharmaceutical industry 5、 According to the action plan, the industrial policy proposes specific policy measures from five aspects: strengthening innovation capacity building, introducing and cultivating advantageous enterprises, supporting product innovation and application, strengthening financial support, and improving the modern pharmaceutical circulation system Among them, the provincial finance will give a one-time reward of 1 million yuan to the top three enterprises that have passed the consistency evaluation of quality and efficacy of generic drugs and the enterprises that have passed the evaluation on schedule In addition, other key agglomeration areas in the province also increased policy support to support the development of biomedical industry Among them, Zhengzhou set up a special fund application enterprise database,