Research on the joint development of biomedical industry in Shenzhen and Hong Kong

The central government supports the construction of an international science and technology innovation center in the Great Bay area of Guangdong, Hong Kong and Macao, and strengthens cooperation in innovation and science and technology among the three regions As an international scientific highland and innovation town, Hong Kong has developed mechanisms of finance, commerce, law and intellectual property rights, and has a good foundation for scientific research, while the huge market and a complete range of industrial bases in the mainland are highly complementary （1） Industrial structure and scale: medical service and industrial service oriented According to the flint creation database, as of August 2019, there were 7776 enterprises in Hong Kong's biomedical field, including only 1849 core industries such as pharmaceutical manufacturing and R & D, and medical device manufacturing enterprises, accounting for 23.8% of all enterprises The total number of medical service enterprises (various clinics, medical institutions, rehabilitation centers, health management and consulting institutions) and industrial service enterprises (financial institutions and media institutions) are relatively large, accounting for 39.3% and 31.6% of the total number of enterprises respectively Figure 1 number and proportion of enterprises in different biomedical fields in Hong Kong, China Data source: flint database （2） R & D capability: strong foundation and strength of scientific research At present, each university in Hong Kong publishes about 250 influential biomedical papers every year, especially in the international large-scale genetic engineering project, SARS (severe acute respiratory syndrome), avian influenza virus and other new infectious diseases, neurological diseases, NPC / lung cancer and other detection and treatment research fields, leading the world Table 1 QS World University Rankings in 2019 (by discipline) At present, Hong Kong has 7 State Key Laboratories in the field of biomedicine It mainly relies on the University of Hong Kong (4), the Chinese University of Hong Kong (2) and the University of science and technology of Hong Kong (1) Table 2 National Key Laboratory of biomedicine in Hong Kong （3） Clinical resources: perfect system, international recognition Hong Kong has a well-known quality medical service system At present, the Hong Kong Hospital Authority administers 43 public hospitals and medical institutions, 49 specialist outpatient clinics and 73 general outpatient clinics Each hospital and outpatient clinic is divided into seven hospital networks according to its area Table 3 public hospitals and medical institutions in Hong Kong Figure 2 Hong Kong's hospital network, distribution of hospitals and medical institutions Photo source: Hong Kong Hospital Authority website The clinical test data of Hong Kong can be approved for drug registration by FDA, EMA, nmpa and other drug regulatory agencies, attracting many multinational pharmaceutical companies to cooperate with medical schools of Hong Kong University and Chinese University of Hong Kong As of April 2019, Prince of Wales Hospital, Mary Hospital, Hong Kong Eye Hospital, Hong Kong nursing hospital and other medical institutions have passed the reexamination and evaluation of the State Drug Administration, and can accept the entrustment of drug registration applicants to carry out approved drug clinical trials （4） Industrial carrier: superior location and perfect service system Hong Kong Science Park Company is the main driving force for the development of biomedical technology in Hong Kong It is committed to promoting the transformation of high-value biomedical research from the experimental stage to the commercialization stage Its Hong Kong Science Park provides a full range of support services for Hong Kong's biomedical industry, including supporting entrepreneurs' biotechnology entrepreneurship and cultivation programs, setting up advanced biology and instrument laboratories, equipped with the latest scientific research instruments, and speeding up the research and development of biomedical scientific research enterprises in high-end medical instruments, molecular diagnosis, stem cell therapy, regenerative medicine, Chinese herbal medicine and advanced therapy The development of door category Hong Kong Science Park is located on the Bank of Tolo Harbour, new territories and adjacent to the Chinese University of Hong Kong At present, more than 100 biomedical enterprises have settled in the park （1） Industrial scale and structure From the perspective of output value scale of pharmaceutical manufacturing industry, in 2018, the pharmaceutical manufacturing industry of Enterprises above Designated Size in Shenzhen achieved an output value of 34.43 billion yuan, ranking first in Guangdong Province In terms of the growth rate of the output value of the pharmaceutical manufacturing industry, the growth rate of the output value of the pharmaceutical manufacturing industry in Shenzhen is 25%, ranking the first in Guangdong Province The biomedical industry in Shenzhen has been in the leading position in Guangdong Province There are 3517 biomedical enterprises in Shenzhen, of which medical devices have become the pillar industry with the absolute advantage of the number of enterprises, 2277, accounting for 65%; among 1240 pharmaceutical enterprises, the number of traditional Chinese medicine enterprises is obviously superior, becoming the leading industry of the pharmaceutical industry Figure 3 distribution of biomedical enterprises in Shenzhen （2） Industrial elements Shenzhen has more than 1 / 3 of listed and new third board enterprises in Jiushi, Dawan District, nearly 1 / 5 of Enterprises above Designated Size, state key laboratories and engineering centers, about 1 / 6 of state-level incubators, accelerators and third class hospitals Table 4 quantity distribution of industrial elements in Shenzhen （3） Industrial layout Shenzhen focuses on gene sequencing, biomedicine and medical devices to form a "dual core and multi center" industrial layout "Dual core" refers to Pingshan national biological industry base and Dapeng International Biological Valley, "multi center" refers to Nanshan medical equipment industry park, Shenzhen high tech Zone biological incubator, Guangming modern biological industry park and other distinctive biomedical industrial parks Figure 4 main areas of biomedical industry in Shenzhen According to the global innovation index 2019, the Shenzhen Hong Kong Science and technology cluster composed of innovation and technology industries in Hong Kong and Shenzhen is the second largest science and technology cluster in the world Shenzhen and Hong Kong should seize the opportunity of development of biological medicine in Dawan District, further deepen cooperation in clinical medicine research, docking of high-quality medical and health resources, standardization of traditional Chinese medicine and marine biological medicine, and explore a new ecological model of production, learning and research innovation in the bay area （1） Space carrier cooperation Hong Kong Shenzhen innovation and technology park is located in the Luomazhou Hetao area bordering Hong Kong and Shenzhen It focuses on the establishment of scientific research cooperation bases, contacts with domestic and foreign top enterprises, research and development institutions and institutions of higher learning, exchanges with outstanding research talents from all over the world, plans to establish offshore innovation bases, and explores and tries out the policies of convenient flow of scientific research materials and special supervision of pharmaceutical and medical devices The government has reserved 20 billion yuan for the development and early operation of the park （2） Cooperation of scientific research institutions In recent years, the cooperation between Hong Kong and Shenzhen scientific research institutions has become closer and closer In the field of biomedicine, the Chinese University of Hong Kong, the Hong Kong University of technology, the City University of Hong Kong, the Hong Kong University of science and technology and so on have jointly established new research institutions in Shenzhen, which are committed to the research and development of cutting-edge fields such as computational biology, regenerative medicine, brain science, biomedical materials and so on Table 5 scientific research institutions jointly established by Hong Kong and Shenzhen （3） Cooperation of medical institutions In recent years, Shenzhen has carried out active and effective exploration in establishing modern hospital management system and deepening medical and health cooperation between Shenzhen and Hong Kong, creating loose conditions for the establishment of medical institutions solely owned by Hong Kong and Macao in Shenzhen At present, there are eight Hong Kong owned medical institutions in Shenzhen In the future, it is hoped to integrate the international medical and health certification and the "top three" review, and promote the Chinese hospital review standards to go international Table 6 cases of cooperation between Hong Kong and Shenzhen medical institutions Apart from technology, Hong Kong has obvious advantages in marketing management, finance and other professional services, which can help bio pharmaceutical enterprises in Shenzhen and even in Dawan district to face various market challenges: (1) Hong Kong has rich financial resources and enjoys the advantage of free circulation of funds Hong Kong Stock Exchange has revised its listing rules, and has accepted a market value of no less than 1.5 billion Hong Kong dollars since April 30, 2018 Relevant listing applications of biotechnology companies can provide more financing channels for relevant enterprises in Dawan district; (2) Hong Kong has a sound legal system and good protection of intellectual property rights and other favorable factors, which are conducive to relevant scientific research activities and technology transactions.