Recently, the Proceedings of the National Academy of Sciences ( PNAS ) published online a collaborative research paper by Professor Chen Xuefeng's group and Zhang Xinghua's group from the Hubei Provincial Key Laboratory of Cell Homeostasis, School of Life Sciences, Wuhan University
PNAS High-fidelity DNA replication and repair are essential for maintaining cell genome stability and normal physiological functions.
Past work has shown that the Saccharomyces cerevisiae transposon regulatory protein Rtt105 interacts with RPA to promote the transport of RPA into the nucleus, and at the same time promote DNA replication by regulating the binding of RPA at the replication fork (Li et al, EMBO J, 2018, Peking University Professor Li Qing's research group)
Furthermore, the authors found that these defects are mainly caused by the reduced binding of RPA to chromatin DNA, not because of changes in the nuclear localization of RPA
Finally, the authors found that the human RPA-interacting protein hRIPα (a potential functional homologous protein of Rtt105) can also promote the assembly of RPA on ssDNA, implying the evolutionary conservation of the above regulatory mechanisms
This research was funded by a general project of the National Natural Science Foundation of China
Related paper information: https://doi.
https://doi.
org/10.
1073/pnas.
2106393118
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