Research reveals a new mechanism that promotes skin wound healing

The confirmed molecular pathway is controlled by an evolutionarily conserved gene called GRHL3, which is a gene necessary for mammalian development

This study reveals how GRHL3 activates a protein-coding gene called fasin Actin-Bundling protein 1 (Fscn1) during wound healing to loosen adhesions between injured skin cells.

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The acute skin wound healing process is divided into four overlapping stages: hemostasis, inflammation, proliferation and tissue remodeling

In the process of re-epithelialization, keratinocytes (cells that make up the outermost layer of the skin) migrate to the top of the underlying granulation tissue, which is a massive pink tissue formed at the edge of the wound

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This work was supported by the National Institutes of Health and the Irving Weinstein Foundation

Journal Reference :

1. Ghaidaa Kashgari, Sanan Venkatesh, Samuel Refuerzo, Brandon Pham, Anita Bayat, Rachel Herndon Klein, Raul Ramos, Albert Paul Ta, Maksim V.