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    Home > Medical News > Medical Science News > Research reveals how aging reduces uveitis

    Research reveals how aging reduces uveitis

    • Last Update: 2021-12-02
    • Source: Internet
    • Author: User
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    November 15, reporters learned from the Zhongshan Ophthalmic Center, the Center Professor Su as a team, following in August this year in the United States , "National Academy of Sciences, the Academy of Sciences" system reveals the effects of aging and gender on the immune system after, and recently joint Chinese Academy of Animal Researchers Liu Guanghui and Qu Jing from the Institute, and Wang Si, a researcher from Xuanwu Hospital of Capital Medical University, and other researchers revealed the mechanism by which aging reduces uveitis


    "National Academy of Sciences after the Academy of Sciences" system reveals the effects of aging and gender on the immune system, and recently joint Chinese Academy of Sciences researcher at the Institute of Zoology and Qu Jing Liu Guanghui, Xuanwu Hospital, Capital Medical University researcher Wang Si and other researchers reveal aging weakened uveitis The mechanism of occurrence


    With the rapid growth of the elderly population, the impact of aging on the body and its relationship with diseases have received more and more attention


    For the first time, this study performed single-cell sequencing of lymph nodes in the normal group and the uveitis model group in young and old mice


    In order to explore the effect of aging on autoimmune diseases, the study was based on a mouse model of autoimmune uveitis, and found that the symptoms of the old model mice are lighter than those of the young model mice


    The researchers found through cell receptor-ligand analysis that aging uveitis mice lacked granulocyte macrophage stimulating factor (GM-CSF) and its receptors


    The researchers further confirmed through in vitro experiments and adoptive transfer experiments that in old mice, the reduction of Th17 cell secretion of GM-CSF leads to the reduction of APCs secretion of IL-23.


    Su Wenru said that the weakened positive feedback effect of "GM-CSF/IL-23/IL23R" on pathogenic Th17 cells may be one of the reasons for the low incidence of uveitis in the elderly


    This study deeply analyzes the mechanism of aging affecting the occurrence of uveitis, and is expected to find new therapeutic targets and treatment methods for the treatment of uveitis


    Related paper information: https://doi.


    https://doi.
    org/10.
    1007/s13238-021-00882-3
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