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A new study conducted by researchers at the University of Illinois Chicago (University of Illinois Chicago) shows that when optic nerve protein (OPTN) is present in cells, it can limit the spread of herpes simplex virus type 1 (HSV-1)
Dr.
The research paper "OPTN is the host's intrinsic limiting factor against neuro-invasive HSV-1 infection", led by Shukla, was recently published in the journal Nature Communications
Researchers are trying to discover why HSV-1 is fatal to people with immunodeficiency, but not to healthy people
This new study reveals the reason why HSV-1 is inhibited: OPTN, a conserved autophagy receptor, selectively targets the HSV-1 protein and degrades it through autophagy.
OPTN prevents the growth of the virus.
The researchers believe that the results of this study will be applicable to all eight different human herpes viruses
In this study, mice with the OPTN gene removed were infected with ocular HSV-1
Shukla said: "Where OPTN and herpes are mutated, you have the formula to create a neurodegenerative disaster
"The study also shows that when OPTN is deficient, the immune response is impaired.
Some of these problems may include neurodegenerative diseases, and researchers believe that further studies may prove this
Shukla said: "We think we will have data showing that other viruses, such as Epstein-Barr virus, Kaposi's sarcoma, and varicella-zoster, will all share this mechanism because they share homologous proteins
Because the herpes virus resides in neurons forever, some people speculate that it is related to neurodegenerative diseases
The study also showed that animals without OPTN and infected with HSV-1 lost the ability to recognize objects after 30 days
Shukla said: "Part of our translational research may be how to correct the OPTN problem so that we don't have neurodegeneration problems
OPTN is a host intrinsic restriction factor against neuroinvasive HSV-1 infection
DOI
https://doi.
