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Researchers design a highly selective RIPK1 inhibitor with a dual mode of action of "alternative + competition"

 Last Update: 2022-01-11
 Source: Internet
 Author: User

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melanocortin receptor

conceptual design phase

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The research team of Zhou Bing, Tang Wei, and Xu Yechun, researchers at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, started with the RIPK1 allosteric inhibitor GSK2982772 in clinical phase II, and carried out structure-based research based on the characteristics of the binding mode of the small molecule and the target protein.

In summary, studies have revealed a class of highly active and selective RIPK1 inhibitors with a novel mode of action, which is expected to provide new strategies for the treatment of systemic inflammatory diseases and neurological diseases

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