Researchers have discovered a new mechanism that regulates the spread of breast cancer

Researchers have known for decades that human cells migrate from one part of the cell to another through circulating cell surface adhesion receptors

The research team of Professor Johanna Ivaska of the University of Turku in Finland has discovered a new mechanism, that is, highly aggressive triple-negative breast cancer cells use integrin circulation and in the tissues Migration

"Human cells first absorb part of the cell membrane and then recycle them to continuously renew their surface

Postdoctoral researcher Paulina Moreno-Layseca and PhD candidate Niklas Jäntti in Professor Ivaska’s research group discovered that breast cancer cells use the molecule swiprosin-1 to guide integrin adhesion receptors to this conveyor belt

By studying hundreds of breast cancer specimens, the researchers found that the high expression of swiprosin-1 molecules in tumors is significantly related to the formation of metastases and the malignancy of breast cancer

"Our findings open up a new perspective on the function of integrins and reveal new mechanisms by which cancer cells can spread throughout the body

DOI

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Article title

Cargo-specific recruitment in clathrin- and dynamin-independent endocytosis