Researchers have discovered a new role in acute myeloid leukemia

A new study led by scientists at Sanford Burnham Prebis University shows that the protein RNF5 plays an unusual role in acute myeloid leukemia (AML)

"AML cells are highly dependent on the RNF5 protein," said Dr.

Ronai's laboratory has been researching RNF5 for 10 years, mainly in breast and skin cancer, and is curious about its role in acute myeloid leukemia, because patients with acute myeloid leukemia have high RNF5 levels often prognosis Bad

Under normal circumstances, as a ubiquitin ligase, RNF5 helps mark other proteins for destruction

"We were very surprised to find that ubiquitin ligase actually regulates gene transcription in AML," said Dr.

The team continues to accumulate evidence that RNF5 and RBBP4 jointly promote AML

These findings may have some therapeutic results

Ronai said: "Patients with lower levels of RNF5 or RBBP4 may respond better to HDAC inhibitors

DOI

10.

RNF5 Regulation of RBBP4 Determines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors