Researchers have discovered how cancer cells that have spread to lymph nodes escape immunologically

Lymph nodes are the key to the human immune system's fight against tumors, but the paradox is that cancer cells spread or metastasize to lymph nodes can often avoid being cleared by immune cells

"We know that lymph nodes are usually the first place to spread during cancer development

By analyzing the tissues of patients with breast cancer, colon cancer, and head and neck cancer, combined with animal models of breast cancer lymph node metastasis, Padera and his colleagues found that there are a large number of immune cells called T cells in metastatic lymph nodes, but they cannot penetrate.

Scientists then developed a device that compresses lymph nodes to simulate the gradual growth of lymph node metastasis

Using the antihypertensive drug losartan to reduce solid pressure can increase the number of blood vessels and T cells in lymph node metastasis, which indicates that reducing solid pressure is a potential strategy for improving T cell entry into tumors

"Our work now raises many important additional questions.

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