Recently, Professor Wang Junjun of the College of Animal Science and Technology of China Agricultural University has made important progress in the research of intestinal flora and metabolites mediated green tea polyphenols to relieve intestinal inflammation.
Microbiome Intrauterine growth restriction (IUGR) leads to high mortality in early life of piglets and poor growth performance in later life.
Based on previous studies, it was found that intestinal microbes play an important role in the occurrence and development of IUGR's enteritis, and the plant extract green tea polyphenol epicatechin gallate (EGCG) has potential beneficial effects in the defense of inflammation
In this study, the author compared the differential effects of oral and rectal treatment of EGCG on mice with ulcerative colitis, and found that oral EGCG can reduce colon inflammation, improve oxidative stress and intestinal barrier dysfunction, but rectal EGCG does not.
On this basis, the author used the feces of EGCG-pretreated mice as the donor to explore the effects of fecal bacteria transplantation and metabolite transplantation to reproduce the relevant phenotypes, and found that the fecal bacteria transplantation (EGCG-FMT) of EGCG-treated mice is more important.
This study took intestinal microbes, functional short-chain fatty acids and epithelial cell homeostasis as the starting point, and found for the first time that microbes and functional short-chain fatty acids play a key role in EGCG regulating colonic epithelial homeostasis and alleviating colitis
Related paper information: https://doi.
https://doi.
org/10.
1186/s40168-021-01115-9
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