Revealthe the fate of senescent cells during embryonic development in mice.

On June 5, the international academic journal Cell Research published the latest research progress of the Research Group of Zhou Bin, Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, embryonic senes cent sed-centre cell cycle and to tissue s tissues.
the study reveals the fate of senescent cells during embryonic development in mice, which are not completely removed, some of which can be retained until after birth, and some cells re-enter the cell cycle for proliferation.
the study broadens awareness of cell aging, suggesting that cell aging may be a temporary cell state and reversible during embryonic development.
cell aging is the weakening of cell proliferation over time or in the face of external stress, which is closely related to the body's aging (aging), a variety of diseases (such as tumors, atherosclerosis, etc.) and post-damage repair of tissue. Recent research
found that in the normal embryonic development of mice, there is the appearance of cell aging in the kidney tube, inner ear lymphatic sac, neural tube and the top exomer layer of the limbs, and revealed that cell aging plays a role in the structural formation of tissue organs during embryonic development.
the study suggests that aging cells are removed later in the embryo.
however, these studies are based on p21 expression and SA beta-Gal staining, and do not explain the true fate of senescent cells.
the study, the researchers first confirmed that they disappeared from E15.5 at the top of the limbs with staining of P21 and SA beta-Gal.
to reveal the fate of embryonic senescent cells, researchers, under the guidance of Zhou Bin, built P21-CreER and P21-tdTomato mice using the molecular marker of embryonic cell aging, and found that labeled cells do not multiply in E11.5 and E12.5 days and express markers, P21, CD44 and HP1.
, the cells marked in E12.5 days were selected by FACS and found that they all exhibited SA beta-Gal activity.
demonstrated that tool mice can label aging cells during the embryonic period in the body, and can use P21-CreER mice to study the fate of senescent cells.
later, the researchers used P21-CreER; R26-tdTomato mice conducted a genealogical tracestudy of aging cells during the embryo and found that the senescent cells at the top of the limbs were not completely removed at E15.5 and E16.5 days, but survived until after birth, but did not express P21 and had no SA-gal activity.
found through EdU and Ki67 staining, tracer sensilated cells enter the cell cycle and multiply again later in embryonic development. The same is true of senescent cells in other aging tissue organs
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discovery is the first to reveal the fate of senescent cells in the body and suggests that cell sensiagesting is a temporary cell state and reversible, providing a new way of thinking for the treatment of diseases caused by cell aging.
the research was supported by Professor Zhu Zhenyu of Jinan University, Professor Kathy Lui of the University of Chinese of Hong Kong, and funded by the Chinese Academy of Sciences, the State Fund Committee, the State Ministry of Science and Technology and the Shanghai Science and Technology Commission.
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