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    Home > Biochemistry News > Microbiology News > Rotavirus Entry into Tissue Culture Cells

    Rotavirus Entry into Tissue Culture Cells

    • Last Update: 2021-02-16
    • Source: Internet
    • Author: User
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    Rotavirus (RV) is a triple-protein-layered icosahedral virus, for which studies have established that the two outer-layer proteins, viral protein 4 (VP4) and viral protein 7 (VP7), are required for viral infectivity (
    1
    ,
    2
    ). VP7, a glycoprotein, is the major component of the outer-layer, but its role in viral entry is unclear. VP4 forms dimers extending out from the VP7-coated viral surface (
    3
    ,
    4
    ) and have been shown to be a determinant of host range and virulence, and is directly involved in cell attachment and RV entry into cells (
    5

    8
    ). Proteolytic cleavage of VP4 into two noncovalently associated subunits, VP8* and VP5* (
    2
    ,
    9
    ,
    10
    ), significantly enhances viral infectivity (
    11

    13
    ).
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