Russian and Israeli scientists find a way to restore protein activity

According to the information technology, machinery and optics Institute of St Petersburg, Russia, in cooperation with Hebrew University in Jerusalem, Israel, the university has found a way to restore the structure of chemically denatured proteins, which can significantly reduce the cost of drug preparation when used to prepare drugs for Parkinson's disease Protein, especially enzyme, can speed up chemical reaction, so it is widely used in medicine and food industry Protein molecules have complex spatial structure, and its spatial structure is directly related to the function of protein If its spatial structure is destroyed, the protein loses its activity A common example is when the egg white is heated and condensed into an opaque form In the process of enzyme production, about 80% of the enzymes lose their activity due to protein denaturation, so it is urgent to find a way to restore protein activity in industrial production In 2015, American chemists successfully recovered the heat denatured egg protein under laboratory conditions, but up to now, scientists have not found an effective way to recover the denatured protein under industrial conditions A team of Russian and Israeli scientists made use of hydrocarbon based alumina nanoparticles to enable the recovery of denatured proteins under industrial conditions The principle is to restore the molecular structure of denatured proteins through the physical action of nanoparticles In practical applications, the protective shell composed of nanoparticles interferes with the aggregation of protein molecules, so it is easier to screen out proteins from the mixed reaction solution Next, proteins recover their molecular structure under the physical effect of nanoparticles The researchers believe that if this method is used in industrial production, it will significantly improve the utilization of enzyme.