Spliceosome-associated factor 1 (SART1) inhibits hepatitis B virus (HBV) new mechanism: on the one hand, SART1 regulates the expression of interferon downstream genes (ISGs); on the other hand, SART1 inhibits it by binding to the hepatocyte nuclear factor 4 (HNF4α) promoter Transcription, and then down-regulate the transcription of hepatitis B virus small chromosome cccDNA
Recently, the Institute of Medical Virology and the State Key Laboratory of Virology, Wuhan University School of Basic Medicine, fixed PI Xia Yuchen's research group with the title "Spliceosome-related factor 1 inhibits hepatitis B virus infection through transcriptional regulation of hepatocyte nuclear factor 4".
There are about 257 million people with chronic hepatitis B infection in the world, and about one-third of them are in China
Researchers used Janus kinases inhibitor Tofacitinib or interferon receptor IFNAR2 knockout to inhibit the interferon pathway
Related paper information: https://doi.
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