Scar removal of old spinal cord injury can activate endogenous neural stem cells

Spinal Cord Injury (SCI) is a common and severe central nervous system injury.

Preliminary studies conducted by the team of Researcher Dai Jianwu from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and Professor Xingjun Jiang’s team from the Department of Neurosurgery of Xiangya Hospital of Central South University have shown that the nerve regeneration scaffold material loaded with paclitaxel can effectively promote the axis of the dog after acute long-distance spinal cord transection.

Based on the above scientific issues, in recent research, the team established an old long-distance spinal cord transection model of large animal beagle dogs, combined the tubulin stabilizing drug paclitaxel on the self-developed nerve regeneration scaffold material, and evaluated once or twice.

The research team completely removed 1 cm of spinal cord tissue from the canine’s thoracic segment (around T8) through surgery to establish a canine model of long-distance spinal cord transection

The results of the study show that implantation of nerve regeneration scaffolds loaded with paclitaxel can promote the recovery of nerve and motor function in dogs with old long-distance total transection of spinal cord injury after the first removal of scar tissue, but the second removal of scar tissue before implantation There is no similar therapeutic effect after this material

The research results have been published in Biomaterials Science , a journal in the field of biomaterials