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July 17, 2021 // - The activation of the hypoxia-inducible factors (HIFs) pathway reprograms the body's energy metabolism, and hemoglobin (Hb) is the main carrier of oxygen
Science Advances .
Image source: https://advances.
Hemoglobin is a special protein in the blood, which is mainly responsible for transporting oxygen to the tissues of the body.
Researcher Professor Juha Auvinen said that we have found a clear association between hemoglobin levels and key cardiovascular health characteristics, and this association will become more pronounced as the subjects age
We found a clear association between hemoglobin levels and key cardiovascular health characteristics, and this association will become more pronounced as subjects age
Hypoxia may protect mice from obesity, metabolic syndrome, fatty liver, and atherosclerosis, and the results of this study demonstrated the relationship between hypoxia and a wide range of metabolic health markers in the human body for the first time
The level of hemoglobin in the human cohort correlates with key anthropometric measurements and oxygen consumption
Image source: Juha Auvinen, et al.
Science Advances
Therefore, a key issue in the future is, if necessary, how to reduce the body's own oxidative reaction level, so as to achieve a permanent low-level activation of the body's HIF response, thereby protecting the body against obesity
Obesity and metabolic syndrome are major health problems in the global population, which are directly related to a variety of comorbidities and premature death of the population; currently half of Finnish adults are overweight, and a quarter of the population suffers Metabolic syndrome; the incidence of obesity in children is also increasing, and the same phenomenon is also very common in the world.
Manipulating the hemoglobin level of the mouse body may mediate changes in key metabolic parameters, and lower levels of hemoglobin may be very beneficial to metabolic health involving mild chronic activation of the HIF response
Original source:
Original source:Juha Auvinen, Joona Tapio, Ville Karhunen, et al.
Juha Auvinen, Joona Tapio, Ville Karhunen, et al.
Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia , Science Advances (2021).
DOI: 10.
1126/sciadv.
abi4822 Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia Science Advances
