Science Advances: Can cancer cells mobilize the nervous system?

Researchers at the Technion-Israel Institute of Technology have developed an innovative breast cancer treatment based on analgesic nanoparticles targeting the nervous system

Breast cancer is one of the most common cancers in women.

Professor Schroeder has many years of experience in developing innovative cancer treatments, including treatments for breast cancer and triple-negative breast cancer

Researchers have discovered that cancer cells have an interrelationship with surrounding nerve cells: cancer cells stimulate nerve cells to infiltrate the tumor, and this infiltration stimulates the proliferation, growth and migration of cancer cells

Based on these findings, researchers have developed a treatment method that uses nerve cells to target tumors

The nanoparticles mimic cell membranes, and the surface is covered with a special polymer, so that they are not affected by the immune system and can circulate in the blood for a long time

Maya Kaduri said: “We know how to make the precise size of the particles needed.

Therefore, the anesthetic particles developed by us move in the bloodstream without penetrating healthy tissues

In cancer cell culture experiments and mouse treatments, the new technology not only inhibited tumor development, but also inhibited metastasis

DOI

10.

Article title

Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases