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The malaria parasite causes hundreds of millions of people to be infected with malaria and more than 400,000 deaths every year
.
, The transmission of malaria is strictly dependent on female Anopheles mosquitoes
So far, there is still no complete answer to the question of whether the motility zygote crosses the midgut epithelium of Anopheles mosquitoes, whether it triggers the host immune recognition and elimination of Anopheles, and how the malaria parasite avoids the host recognition of Anopheles mosquitoes
.
In July 2021, Professor Yuan Jing's research group published a research paper entitled A malaria parasite phospholipid flippase safeguards midgut traversal of ookinetes for mosquito transmission in Science Advances
Professor Jing Yuan’s research group focused on the study of the molecular mechanism of Plasmodium Anopheles transmission (EMBO Reports 2021, Nature Communications 2020, EMBO Journal 2020, Current Biology 2018, mBio 2017, 2014)
.
In eukaryotic cell organisms, P4-ATPase functions as Flippase and plays an important role in a variety of cellular processes
How does ATPase7 work? The research team found that after the deletion of ATPase7, the ability of the mobilizer to transport PC (phosphatidylcholine) to the inside of the cell was significantly reduced, while the intracellular transport capacity of several other phospholipids was not affected.
It is inferred that the transport substrate of ATPase is PC
.
The loss of ATPase7 leads to the accumulation of PC on the outer side of the plasma membrane of the zygote cell
Interestingly, the ATPase7-deficient zygote was injected directly into the blood cavity of Anopheles to artificially cross the physical barrier of the Anopheles midgut epithelium.
The ATPase7-deficient zygote could develop into oocysts and sporozoites, completing the malaria parasite in the Anopheles host.
Parasitic development
.
This result further shows that ATPase7 specifically plays an essential role in the process of the Plasmodium mobilizer crossing the midgut epithelium of Anopheles mosquitoes
The work was completed by PhD graduate Yang Zhenke (first author), PhD student Shi Yang (co-first author), PhD student Yang Shuzhen (participating author); Professor Yuan Jing is the corresponding author
.
The research was funded by the National Natural Science Foundation of China
Link to the full text of the paper:
https://advances.
