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Editor’s note iNature is China’s largest academic official account.
It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
The iNature Talent Official Account is now launched, focusing on talent recruitment, academic progress, scientific research information, and interested parties.
Long press or scan the QR code below to follow us.
The inner and outer hippocampal loops of iNature mammals prioritize spatial and object-related information respectively.
However, the mechanism by which this parallel loop is assembled during development remains largely unknown.
On June 4, 2021, Liqun Luo's team from Stanford University published a research paper titled "Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks" in Science.
The study found that the cell surface in the inner and outer hippocampal loops in mice The complementary expression of molecules teneurin-3 (Ten3) and latrophilin-2 (Lphn2) respectively guide the precise loop assembly of CA1 to subiculum connection.
In the medial loop, the (Ten3+) CA1 axons expressing Ten3 are rejected by the derived Lphn2, indicating that Lphn2 and Ten3 mediated heterophilic rejection and Ten3-mediated homophilic attraction jointly control the precise target of CA1 axons select.
In the lateral network, CA1 axons expressing Lphn2 (Lphn2+) are confined to the Lphn2+ target by repulsion from the Ten3+ target.
The results of this study indicate that the assembly of parallel hippocampal loops follows the "Ten3→Ten3, Lphn2→Lphn2" rule indicated by mutual exclusion.
With repeated use in various connections combined with versatility, where a single protein acts as both a receptor and a ligand, a limited number of cell surface molecules can specify the diverse connections in the mammalian brain.
Parallel information processing is a prominent feature of the complex nervous system.
An example is the mammalian hippocampus-entorhinal loop, which is essential for dominant memory formation and spatial representation.
Space and object-related information are preferentially processed by the inner and outer hippocampal loops, respectively.
In the medial loop, the proximal CA1 axon projects to the distal subiculum, and the proximal CA1 and distal subiculum also form an interconnection with the medial entorhinal cortex.
In the lateral loop, the distal CA1 axons project to the proximal underpin, and the distal CA1 and the proximal underpin are interconnected with the outer entorhinal cortex.
The type II transmembrane protein Tenurin-3 (Ten3) has matched expression in all interconnected regions of the medial hippocampal loop.
Ten3 is needed in both the proximal CA1 and the distal receptacle to select the axons of the proximal CA1→the distal receptacle, which promotes the aggregation of non-adherent cells.
These data support the homogeneous attraction mechanism through which Ten3 regulates target selection in the medial hippocampal loop.
It is unclear whether there is matched gene expression in the lateral hippocampal loop and how this contributes to hippocampal loop assembly.
The study found that in mice, the complementary expression of the cell surface molecules teneurin-3 (Ten3) and latrophilin-2 (Lphn2) in the medial and lateral hippocampal loops respectively directs the precise loop assembly of CA1 to the subiculum.
In the medial loop, the (Ten3+) CA1 axons expressing Ten3 are rejected by the derived Lphn2, indicating that Lphn2 and Ten3 mediated heterophilic rejection and Ten3-mediated homophilic attraction jointly control the precise target of CA1 axons select.
In the lateral network, CA1 axons expressing Lphn2 (Lphn2+) are confined to the Lphn2+ target by repulsion from the Ten3+ target.
In summary, the results of this study indicate that the assembly of parallel hippocampal loops follows the "Ten3→Ten3, Lphn2→Lphn2" rule indicated by mutual exclusion.
With repeated use in various connections combined with versatility, where a single protein acts as both a receptor and a ligand, a limited number of cell surface molecules can specify the diverse connections in the mammalian brain.
Reference message: https://science.
sciencemag.
org/content/372/6546/1068
It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
The iNature Talent Official Account is now launched, focusing on talent recruitment, academic progress, scientific research information, and interested parties.
Long press or scan the QR code below to follow us.
The inner and outer hippocampal loops of iNature mammals prioritize spatial and object-related information respectively.
However, the mechanism by which this parallel loop is assembled during development remains largely unknown.
On June 4, 2021, Liqun Luo's team from Stanford University published a research paper titled "Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks" in Science.
The study found that the cell surface in the inner and outer hippocampal loops in mice The complementary expression of molecules teneurin-3 (Ten3) and latrophilin-2 (Lphn2) respectively guide the precise loop assembly of CA1 to subiculum connection.
In the medial loop, the (Ten3+) CA1 axons expressing Ten3 are rejected by the derived Lphn2, indicating that Lphn2 and Ten3 mediated heterophilic rejection and Ten3-mediated homophilic attraction jointly control the precise target of CA1 axons select.
In the lateral network, CA1 axons expressing Lphn2 (Lphn2+) are confined to the Lphn2+ target by repulsion from the Ten3+ target.
The results of this study indicate that the assembly of parallel hippocampal loops follows the "Ten3→Ten3, Lphn2→Lphn2" rule indicated by mutual exclusion.
With repeated use in various connections combined with versatility, where a single protein acts as both a receptor and a ligand, a limited number of cell surface molecules can specify the diverse connections in the mammalian brain.
Parallel information processing is a prominent feature of the complex nervous system.
An example is the mammalian hippocampus-entorhinal loop, which is essential for dominant memory formation and spatial representation.
Space and object-related information are preferentially processed by the inner and outer hippocampal loops, respectively.
In the medial loop, the proximal CA1 axon projects to the distal subiculum, and the proximal CA1 and distal subiculum also form an interconnection with the medial entorhinal cortex.
In the lateral loop, the distal CA1 axons project to the proximal underpin, and the distal CA1 and the proximal underpin are interconnected with the outer entorhinal cortex.
The type II transmembrane protein Tenurin-3 (Ten3) has matched expression in all interconnected regions of the medial hippocampal loop.
Ten3 is needed in both the proximal CA1 and the distal receptacle to select the axons of the proximal CA1→the distal receptacle, which promotes the aggregation of non-adherent cells.
These data support the homogeneous attraction mechanism through which Ten3 regulates target selection in the medial hippocampal loop.
It is unclear whether there is matched gene expression in the lateral hippocampal loop and how this contributes to hippocampal loop assembly.
The study found that in mice, the complementary expression of the cell surface molecules teneurin-3 (Ten3) and latrophilin-2 (Lphn2) in the medial and lateral hippocampal loops respectively directs the precise loop assembly of CA1 to the subiculum.
In the medial loop, the (Ten3+) CA1 axons expressing Ten3 are rejected by the derived Lphn2, indicating that Lphn2 and Ten3 mediated heterophilic rejection and Ten3-mediated homophilic attraction jointly control the precise target of CA1 axons select.
In the lateral network, CA1 axons expressing Lphn2 (Lphn2+) are confined to the Lphn2+ target by repulsion from the Ten3+ target.
In summary, the results of this study indicate that the assembly of parallel hippocampal loops follows the "Ten3→Ten3, Lphn2→Lphn2" rule indicated by mutual exclusion.
With repeated use in various connections combined with versatility, where a single protein acts as both a receptor and a ligand, a limited number of cell surface molecules can specify the diverse connections in the mammalian brain.
Reference message: https://science.
sciencemag.
org/content/372/6546/1068
