Science does not reduce calorie intake, but it increases the underlying mechanisms of thermogenesis

The researchers report that mice that ate during the active phase of the daily diurnal cycle burned more calories by enhancing thermogenesis, which slowed the progression of
obesity.
These findings help explain the underlying mechanisms underlying the benefits of time-restricted eating and how circadian rhythm disturbances can lead to metabolic diseases
.
While previous studies have shown that the timing of eating contributes to obesity and other metabolic diseases relative to the day-night cycle of daily activity and sleep, the mechanisms remain unclear
.
To help shed light on these details, Chelsea Hepler and colleagues evaluated the effects of
time-restricted feeding (TRF) on mice fed high-fat feed (HFD).
Through a series of experiments, Hepler et al.
found that when rats were fed HFD during the active phase of their daily diurnal cycle (at night, because mice are nocturnal), they burned more calories through fat cell thermogenesis, which protected them from diet-induced obesity
.
The findings suggest that this enhanced thermogenesis relies on the circadian clock of fat cells and an ineffective creatine cycle
.
In mouse models with reduced adipocyte creatine levels, thermogenesis was not enhanced when feeding was synchronized with the active phase, resulting in weight gain
similar to feeding error times.
Damien Lagarde and Lawrence Kazak write in a related opinion: "The application of TRF in humans appears to be a promising approach to weight loss and improved metabolic health with few
side effects.
" The work of Hepler et al.
expands our understanding of
the TRF earning mechanism.
”

Time-restricted feeding mitigates obesity through adipocyte thermogenesis