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Science: Follicles produced by mouse pluripotent stem cells can produce viable oocytes

 Last Update: 2021-07-29
 Source: Internet
 Author: User

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induced pluripotent stem cells

ability culture stem cells important

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According to a new report, the researchers used mouse embryonic stem cells to reconstruct the structure of the follicles and used them to mature primordial germ cells into fully functional oocytes in vitro, ultimately producing viable mouse offspring

Inducing germ cell precursors into functionally mature germ cells is a key aspect of in vitro gametophyte development, and it is also a major challenge in the study of reproductive biology

In mammalian species, oocytes grow and mature in follicles, which are special fluid-filled sacs that provide signals for meiosis and germ cell growth

When FOSLCs are combined with PGCLCs of mouse embryonic stem cells, PGCLCs develop into fertile oocytes in the reconstructed follicular structure.

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