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The top two images show a stressful stem cell, shown by the calreticulin (yellow spike) expressed on its surface, which is engulfed and engulfed
by macrophages.
The two panels at the bottom show a healthy stem cell that expresses very little calcaretin that is touched by macrophages but not engulfed
.
Instead, macrophages appear to pull some material
out of the cells.
Calcaretin acts as a "eat me" signal
.
Using real-time imaging and cellular barcoding, researchers in Boston Children's Hospital's stem cell program have glimpsed how neonatal stem cells are being reviewed for quality shortly after birth, in this case blood stem cells
.
Led by Sam Wattrus, a doctoral candidate in Leonard Zon's lab, the researchers used zebrafish models to observe stem cell development
.
"Whenever a macrophage interacts with a cell, it absorbs a lot of biological information," Wattrus said
.
Potential impact on cancer and regenerative medicine
The team also observed similar macrophage-stem cell interactions
in embryonic mice.
In the cancer community, cancer cells can send out "don't eat me" signals to evade attacks by our immune system, and people are interested in
blocking these signals with antibodies to defeat cancer.
Zon speculates: "There may be a way to use small molecules to put pressure on cells, causing the cell surface to produce calcareticin, which leads to the aggressive clones being eaten
.
If so, it could have a huge potential impact on
lifelong health.
Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality
