Science Revealed: How does a sudden, unexplainable heart attack happen?

When Christian Eriksen, the top international football player, fell during the European Cup, the whole world suddenly realized this sudden and unexplainable heart attack

When Erickson stabilized, he was not the only one who experienced this situation

In a new study, researchers from the Department of Drug Design and Pharmacology used a new technique to gain insights into this phenomenon

"We know that some of these attacks are caused by a malfunction of a certain protein on the cell membrane of heart cells

Phosphorylation is the process of modifying a protein and changing its function

The combination of genetic mutations and chemical modifications can cause the protein to lose its function, causing the heart to stop functioning

Protein engineering

To test their hypothesis, the researchers used a new technique to manipulate proteins through chemical modification, in this case phosphorylation

Instead, researchers can insert short synthetic amino acid sequences containing mutations or modifications into proteins

"The previous problem was that we couldn't control the degree of phosphorylation through experiments, because at any given time, cells containing proteins would regulate the level of phosphorylation

"This technology allowed us to study a mutation adjacent to phosphorylation for the first time.

This discovery lays the foundation for further research on the effects of modifications on the proteins in heart cells and their response to drugs

Original title:

Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

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