"Science" reveals a new defense mechanism: the gut has innate immune memory

The innate immune system plays a crucial role in regulating host-microbe interactions, especially preventing pathogens from invading the mucosa

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The intestinal mucosa possesses a complex defense system to resist pathogenic infection while maintaining tolerance to the commensal microbiota, which is essential for normal bodily function

▲ ILC3 in the gut (Image credit: Nicolas Serafini – Institut Pasteur/Inserm)

In 2008, a team led by Professor James Di Santo of INSERM described innate lymphocytes type 3 (ILC3) as a new family of lymphocytes distinct from adaptive B and T cells

In the latest study, scientists used an innovative protocol to briefly expose the immune system to Citrobacter murine

▲Tr-ILC3s effectively control pathogenic bacteria to attack stem cells and blastocysts (Source: Reference [1])

The ability to "train" the innate immune system in the mucous membrane can greatly improve the body's defenses against a variety of pathogens

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References:

[1] Nicolas Serafini et al.