Science sub-Journal accidentally found a way to eliminate super bacteria

Superbugs such as methicillin-resistant Staphylococcus aureus (MRSA) are now circulating in many hospitals in the United States, posing a serious public health threat and a global focus of disease control

Scientists at Johns Hopkins University School of Medicine discovered by accident that full suppression of all caspases is a promising immunotherapy, which targets the host's immune system to fight MRSA and other bacterial skin infections

The research published in the article in "Science Translational Medicine", "Pan-caspase inhibition as a potential host immunotherapy against MRSA and other bacterial skin infections" was funded by the National Institutes of Health (NIH), It is the basis of patent applications

"Alexander Fleming’s accidental discovery led to the golden age of antibiotics, but now the age of antibiotics is coming to an end due to the emergence of antibiotic-resistant bacteria," said Lloyd Miller, MD, a former Johns Hopkins Professor of Dermatology, Infectious Diseases and Plastic Surgery at the University School of Medicine

Miller said that the initial focus of the research team was to study the mechanisms behind MRSA skin infections in mouse models that cannot synthesize interleukin-1β (IL-1β)

Miller said: "We gave mice a blocker of all pancpasase inhibitors, a compound called Q-VD-OPH, and thought it would make two groups of mice [with and without IL] -1β] is more susceptible to MRSA infection

In order to confirm that this accidental discovery was not accidental, but a viable method to suppress the deadly MRSA infection, Miller and his colleagues conducted other experiments with encouraging results

A single oral dose of Q-VD-OPH reduces the size of methicillin-resistant Staphylococcus aureus skin lesions and quickly removes bacteria with vehicle-treated (considering that the operator solution does not have Q-VD-OPH) and untreated small Rats," said Martin Alfons, Ph.

Alphonse said that Q-VD-OPH reduced the apoptosis of neutrophils and monocytes, making them abundant and better able to eliminate MRSA bacteria

Miller said: "It's like a fire department.

Studies have shown that in addition to increasing apoptosis, pancpasase inhibitors can also increase the necrosis of mature monocytes (also known as macrophages)

Alphonse said: "Destroying macrophages through necrosis releases large amounts of TNF, a protein that triggers anti-bacterial immune cells to flood the infected area of ​​the skin

The researchers tested whether Q-VD-OPH has broader activity in mice against two other dangerous skin bacteria-Streptococcus pyogenes and Pseudomonas aeruginosa

Facts have proved that ubiquitin inhibitors target the human immune system to fight bacteria, and the effect of eliminating these two bacterial strains is as successful as the effect of eliminating MRSA