Science Sub-journal: Revealing the role of androgen receptors in advanced prostate cancer

Androgen receptors (ARs) are a driver of cell differentiation and prostate cancer, and are a common therapeutic target for prostate cancerA great deal of research has linked these normal and abnormal cellular processes to mRNA transcription; however, the extent to which androgen receptors regulate gene regulation after transcription remains unknownIn a new study, researchers from the Fred Hutchinson Cancer Research Center, the University of Washington and Memorial Sloan Kettering Cancer Center confirmed that androgen receptors use translation compounds to shape cell proteomicsThey found that androgen receptors were a negative regulator yroining factor synth of proteins, and identified an unexpected association between androgen receptors and the process of translation in vivo translation: the lack of such receptors was associated with increased translation initiationThis is mediated by direct transcription control of translation suppressor 4EBP1This observation helps explain the rapid growth of advanced prostate cancer, which lacks androgen receptorsThe findings were recently published in the journal Science Translational Medicine under the title "The androgen regulates a druggable translation al-gulean in the advanced prostate cancer"these researchers have shown that reducing the abundance of androgen receptors increases the assembly of eIF4F translation starting complexes, thereby promoting the proliferation of increased tumor cellsin addition,, the researchers revealed a proliferating mRNA network characterized by a smooth regulatory element rich in otolyl, which is particularly sensitive to eIF4F activityUsing genetic and drug methods, they confirmed that the dissociation of eIF4F complexes can reverse this proliferation procedure, leading to reduced tumor growth and increased survival in preclinical modelsthese findings reveal a drug-targeted correlationIn a class of prostate cancer that lacks androgen receptors, this correlation is functionally associated with the mRNA transcription process and the translation initiation processoriginal origin: Yuzhen Liu et alThe androgen regulates a druggtranslationable al regulon in advanced prostate cancerScience Translational Medicine, 2019, doi:10.1126/scitranslmed.aaw4993.