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Indiana Jones hates snakes
Kibret Mequanint is not particularly fond of these slippery reptiles (in fact, he also hates them), but this Western University bioengineer and his international collaborators have discovered a new use of snake venom: a kind of human tissue.
In the past 20 years, Mequanint has developed a number of medical devices and treatment technologies based on biomaterials, some of which may be licensed to medical companies or in advanced stages of preclinical testing
His latest collaborative research findings are based on a type of blood thrombin, namely crawling enzyme or Dongling enzyme, which is found in the venom of the Hydralisk (Bothrops atrox), which is one of the most venomous snakes in South America.
Using this coagulation property, Mequanint and an international research team designed a human tissue adhesive that combines this special enzyme into a modified gelatin, which can be encapsulated in a small test tube, which is easy to use and may save lives
"In the event of trauma, injury and emergency bleeding, this'super glue' can be applied by simply squeezing the tube and irradiating it with visible light (such as a laser pointer) for a few seconds
Compared with clinical fibrin glue, which is considered to be the industry gold standard for clinical and field surgeons, the new tissue sealant has 10 times the adhesive strength to resist peeling or flushing caused by bleeding
This new biotechnology can reduce blood loss and save more lives
Mequanint said: "We envision this organization's "super glue" will be used on the battlefield to save lives, or other accidental trauma, such as car accidents
In addition, this new type of snake venom "superglue" can be used for sutureless surgical wound closure
Today, a hemostatic bioadhesive gel of snake extract cross-linked with visible light was published in the journal "Science Advances"
Mequanint said: "The next phase of research is underway to transform the discovery of tissue'super glue' into clinical research
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