【Science Sub-journal】After changing an organ, how serious are the consequences of intestinal microbiome dysbiosis?

This article is the original of translational medicine network, please indicate the source when reprinting

Author: Lily

For patients in the terminal stages of the disease, organ transplantation is a life-saving method

On August 31, a research team from the University of Groningen in the Netherlands published a research paper titled "Gut microbiome dysbiosis is associated with increased mortality after solid organ transplantation" in the journal Science Translational Medicine

the study sample

 01 

Previous studies on the gut microbiome after solid organ transplantation, overwhelmingly small samples, lack longitudinal and long-term data; And both used 16S nuclear proteosome RNA (rRNA) marker gene sequencing— which provides only limited resolution and microbial taxonomy coverage — and therefore could not functionally characterize

To overcome these limitations, the researchers used shotgun metagenomics to sequence 1370 stool samples: 415 liver transplant recipients (LTRs) and 672 kidney transplant recipients (RTRs) from the TransplantLines Biobank and Cohort Study

Taxonomic and metabolic changes occurred in the gut microbiome

 02 

The study observed that the composition of the gut microbiome of LTR and RTR showed significant changes

Figure below: Characterization of altered taxa in the gut microbiome after transplantation compared to the general population control group (GPC).

(A) Principal components reflect the distance of Aitchison from the relative abundance of species-level RCLR transforms produced by DEICODE

(B) Violin diagram depicting GPC (blue), LTR (orange; PLTR vs HC = 3.

(C) Evolutionary branch diagram depicts the results of

The color of these dots indicates importance: green represents a rich taxon of significant differences shared between LTR and RTR; Blue represents taxa with a significant difference abundance that is only significantly different in RTR, and orange represents taxa that is significantly different and abundant only in LTR

In addition, the research team also demonstrated that the use of immunosuppressive drugs is associated with the observed ecology of the gut microbiome; The degree of dysbiosis is associated

Limitations and prospects of research

 03 

The study has several limitations that should be addressed

Currently, promising breakthroughs are being made in the field of pharmacology, but more research is needed on the complex interactions between the gut microbiome and immunosuppressive drugs to improve health outcomes

Resources:

This article is intended to introduce the progress of medical research and cannot be used as a reference for
treatment options.

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