Science: the high fructose corn syrup in the drink can promote the growth of colon cancer in mice!

April 28, 2019 / bioin / - obesity increases a person's risk of multiple cancers, including rectal cancer One of the factors contributing to the rise in obesity is the use of high fructose corn syrup (HFCS) as a sweetener in soft drinks Goncalves et al From Cornell Medical School in will found that HFCS can promote the growth of colorectal cancer even in mice without obesity An enzyme (kethexokinase) in tumors can transform fructose into fructose-1-phosphate, which can change the metabolism of tumor cells and promote cell growth Photo source: Science drinking too much high fructose corn syrup (HFCS) can lead to obesity and increase the risk of colorectal cancer It is not clear whether HFCS directly causes tumor Goncalves et al Studied the effect of daily oral HFCS on adenomatous polyposis (APC) mutant mice prone to intestinal tumors The researchers found a significant increase in tumor size and tumor grade in mice taking HFCS orally without obesity and metabolic syndrome In addition, the researchers also observed that high fructose corn syrup increased the concentration of fructose and glucose in the intestinal cavity, respectively, and the tumor would transport the two sugars Within the tumor, fructose is converted into fructose-1-phosphate, which leads to the activation of glycolysis and the increase of fatty acid synthesis supporting tumor growth These mouse studies support the hypothesis that eating a diet containing both glucose and fructose, even at a moderate dose, can increase tumor development But it remains to be seen whether a similar process will take place in humans Reference: Marcus D Goncalves et al High fructose core syrup enhancements internal tumor growth in mice Science Doi: 10.1126/science.aat8515