Science: The newly discovered role of "good cholesterol"-protecting the liver

The research was published in the July 23 issue of "Science"

As we all know, high-density lipoprotein is mainly used to remove cholesterol in the body and transport it to the liver for processing

Corresponding author of the article, Dr.

Any kind of intestinal injury can affect the impact of a group of microorganisms called gram-negative bacteria on the body

Some premature babies suffer from a fatal disease, necrotizing enterocolitis, which is an inflammation of the intestines that requires surgery to remove part of the intestine

They studied this problem in a mouse model: removed part of the small intestine of the mouse and studied the resulting liver fibrosis

"However, no one thinks that HDL will move directly from the intestine to the liver, which requires it to enter the portal vein.

HDL3 walks a short distance along the portal vein.

HDL3 is a complex of protein and fat.

"We believe that only when LBP binds to HDL3 will it physically hinder it, so lipopolysaccharide cannot activate inflammatory immune cells.

Researchers have found that when HDL3 in the intestine is reduced, if part of the intestine is surgically removed, liver damage will be more serious

In all these intestinal injury models, the researchers found that HDL3 has a protective effect.

The researchers further showed that the same protective molecular complex also exists in human blood samples, indicating that a similar mechanism exists in humans

Randolph said: "We hope that HDL3 can be used as a target for the treatment of liver disease in the future

(Biology: Wanwen)

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