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《Science》Single-cell spatial resolution chromatin modification map

 Last Update: 2022-03-07
 Source: Internet
 Author: User

Chromatin modification close-up

Despite recent advances in spatial transcriptomics in mapping gene expression, it has not yet been possible to identify the underlying epigenetic mechanisms that control gene expression and tissue development with high spatial resolution
.
Yanxiang Deng et al.

of the Department of Biomedical Engineering at Yale University have created a

A technique known as Spatial Cut and Tag (CUT&Tag), which enables genome-wide analysis of histone modifications on a pixel-by-pixel basis on undissociated frozen tissue sections

In this article, we combine in situ CUT&Tag, microfluidic deterministic barcoding, and next-generation sequencing for genome-wide spatial analysis of histone modifications

Spatially resolved states of mouse embryonic chromatin reveal tissue-type-specific epigenetic laws, consistent with encoded references, and provide spatial information at the tissue scale

Spatial CUT&Tag reveals epigenetic control of the spatial pattern of mouse cerebral cortex development and cell types determined by histone modifications

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