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| Scientists build a platform to analyze age-related immune and gene expression changes |
Recently, Briefings in Bioinformatics published online the latest research results of the He Chunjiang group of the School of Biomedicine and Health of Huazhong Agricultural University.
The research established a platform ADEIP for displaying and searching age-related gene expression and immune profiles
.
ADEIP includes gene expression data from more than 16,000 samples of 30 major human tissues in the GTEx program, which come from donors in the age range of 20 to 80
.
This study conducted an integrated analysis of the differentially expressed genes and gene sets, immune-related genes and immune cell composition of different age groups
.
At the same time, the genes known to be related to SARS-CoV-2 and human mesenchymal stem cells were analyzed by examples, and the related applications of ADEIP were demonstrated
As a more comprehensive platform, ADEIP can be used to study aging-related expressions and cross-organizational immune maps, helping to understand the mechanisms of age-related infectious or genetic diseases, so as to develop personalized treatment plans
.
(Source: China Science News Li Chen)
Related paper information: https://doi.
Related paper information: https://doi.
org/10.
1093/bib/bbab274 https://doi.
org/10.
1093/bib/bbab274
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