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| Scientists discover genetic variation associated with menopause |
A large-scale genome-wide association study published by Nature on August 4 found 290 genetic variants associated with menopausal age
.
Scientists pointed out that for this biological mechanism that determines reproductive lifespan, the cognition brought by this research may guide future research and help find new ways to treat infertility and prevent diseases
.
On average, most women's menopause occurs between the ages of 50 and 52
.
Women who start menopause have a decreased natural fertility and an increased risk of fractures or diseases such as type 2 diabetes
In this latest study, John Perry of the University of Cambridge and his colleagues analyzed the genetic data of 201323 women of European descent who had natural menopause between 40 and 60 years old
.
Through the analysis of approximately 13.
1 million genetic variants, the research team discovered 290 determinants of ovarian aging related to postmenopausal delay
.
A large number of DNA damage response genes have been found to be associated with natural menopausal age.
The researchers conducted specific experiments on two of the mice's genes-Chek1 and Chek2-and the results showed that they can affect the fertility and reproductive life of the mice
.
Further genetic analysis of humans has shown that there is a causal relationship between delayed menopause and improved bone health and decreased incidence of type 2 diabetes
Although many factors affecting reproductive age are still unknown, including non-genetic factors, scientists hope that the above findings can guide follow-up experimental research and find new ways to strengthen female reproductive function and extend fertility
.
(Source: China Science News Zhao Xixi)
Related paper information: https://doi.
https://doi.
org/10.
1038/s41586-021-03779-7
![9-[1,1'-biphenyl]-4-yl-3,3'-Bi-9H-carbazole](https://file.echemi.com/fileManage/upload/category/ac71ac0d-8ef6-11ec-89e5-fa163ed06441.png)
