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| Scientists discover new pathways that nutrient signals regulate epigenetics |
Recently, a new study by the Zhao Shimin team/Xu Wei team of Shanghai Medical College of Fudan University has discovered a new signaling pathway that can integrate nutritional signals, cell cycle signals, and transcriptional activation, revealing a new way for the metabolic environment to change the appearance of cells and regulate cell proliferation.
The mechanism also provides new ideas for the intervention of diseases related to metabolic disorders such as cancer
.
The research results were published in "Nature-Metabolism"
Adequate nutrition is a necessary condition for cell proliferation and tissue development
.
Cell proliferation and tissue development require up-regulation of histone acetylation to activate gene transcription
The latest research results of Zhao Shimin's team/Xu Wei's team show that metabolite signals and cell cycle signals jointly regulate histone acetylation to achieve gene transcription activation
.
Under the condition of abundant nutrient metabolites, the signal of the eutrophication sensor mTORC1 in the cell is activated, so that the cell is in a state where it can undergo anabolism and proliferation
CDK2, which has received the eutrophication signal, does not enter the nucleus directly.
It phosphorylates a glycosylase called triose phosphate isomerase (TPI1) and introduces it into the nucleus
.
TPI1 entering the nucleus can reduce the promotion of histone deacetylation by DHAP by generating a new metabolite acetyl DHAP, which in turn leads to the activation of histone acetylation and gene transcription to achieve cell proliferation
Related paper information: https://doi.
https://doi.
org/10.
1038/s42255-021-00405-8
