Scientists discover the biological mechanism of ozone-induced cardiovascular and metabolic diseases

Recently, the research group of Professors Kan Haidong and Chen Renjie of the School of Public Health of Fudan University , through a randomized cross-over study, found that ozone exposure harms the cardiac autonomic nerve and neuroendocrine system
.

It is reported that ozone usually exists in the upper atmosphere about 30 kilometers from the ground.
It can effectively block ultraviolet rays and protect human health
.

In order to clarify this problem, the research team of Kan Haidong and Chen Renjie used the exposure chamber to precisely control individual exposure levels, and compared the differences in heart rate variability, stress hormone levels and serum metabolomes of volunteers after exposure to ozone and clean air
.

Heart rate variability can objectively reflect the status of sympathetic and parasympathetic nerves in cardiac autonomic nerve function
.

Because the study adopted a random cross-control design and strictly controlled exposure conditions, it solved the problem of exposure measurement errors in previous environmental epidemiology, and provided strong evidence for ozone-induced changes in cardiovascular system subclinical indicators and molecular biology.
The biological mechanism of ozone-induced cardiovascular and metabolic diseases provides new insights
.

Kan Haidong said that ozone attenuates significantly from outdoor to indoor.
For the sake of health, it is recommended that sensitive people should try to avoid outdoor activities in the afternoon when the light is strong, the temperature is high, and the humidity is low
.

Related paper information: https://doi.