Scientists first decipher the "road map" of cancer-related proteins

  Researchers at the University of Toronto and other institutions have unveiled the mystery of an important protein related to diseases, which will help develop new methods to treat cancer, cystic fibrosis and other diseases
In the study, published in the journal Nature Chemical Biology, scientists first revealed the action roadmap of ATP binding cassetter (ABC) transporter proteins   This kind of protein is an important component for every cell It is a kind of membrane protein that can utilize ATP hydrolysis energy to transport a series of compounds through the membrane structure against the concentration direction These proteins can transport ions, sugars, amino acids, vitamins, polypeptides, polysaccharides, hormones, lipids and bioheterologous substances In recent years, many studies have involved how to reverse multidrug resistance caused by ABC transporters In recent years, many studies have involved how to reverse the multidrug resistance caused by ABC transporter   Scientists have been trying to understand how this protein performs its function and interacts with other proteins The researchers solved this problem by using yeast two hybrid (myth) technology, and found the mechanism of how these transporters interact with other key components in the cell   The researchers said that the cell system is very complex To understand how certain diseases occur and the best treatment plan, we need to really master how individual components are combined   As the gatekeeper of cells, ABC transporter can conserve nutrients for cells and excrete toxins If these proteins don't work properly, they can lead to diseases such as cystic fibrosis, age-related macular degeneration, Tangier's disease, Dubin Johnson syndrome, etc Moreover, ABC transporters can also cause cancer cells to be resistant to chemotherapy drugs, with poor therapeutic effect   Finding out how ABC transporters affect the mechanisms of cancer and other diseases will help to develop better, more targeted drugs, the researchers concluded This is the real significance of the study.