Scientists have discovered new mechanisms for RNA methylation to regulate sperm development

Qi and Li Wei of the Institute of Zoology of the Chinese Academy of Sciences, in collaboration with the Yang Yungui Research Group of the Beijing Genomics Research Institute of the Chinese Academy of Sciences, revealed the m-technology of mettl3
A (6-thyroid gland) modifies the new mechanism that regulates the starting process of differentiation and subtracting of spermogen stem cells. The research, titled Metall3-mediated m
A regulates spermatogonial and meio launchsision, was published online
15 August.
's team first used CRISPR-Cas9 technology to build mice in reproductive cells that were conditionive to knock out Mettl3, revealing the male infertility and smaller testicles in Mettl3, and further studies showed that Mettl3 knock-off caused abnormal differentiation of testicular sperm cells in mice, and the start of subtracting was blocked. After obtaining Metall3 to remove the sterility esoteric type in mice, it was found that Mettl3 deficiency led to changes in the expression of genes associated with sperm, including sperm stem cell maintenance, differentiation, and decommissioning. The m
A-miCLIP sequencing combined with a single base resolution found that mettl3-mediated m
A modification regulates variable shearing of genes associated with sperm, resulting in abnormal sperm processes.
the team discovered the mRNA-mediated RNA methylation modified m-modification m in a
A methylation point selectivity mechanism (Chen et al. Cell Stem Cell 2015), the above-mentioned Mettl3-mediated m
A regulates the initial mechanism of differentiation and subtracting of spermogen stem cells, which provides a basis for further study of the biological function of RNA methylation regulation and RNA supergenetics, and provides a new direction for the study of molecular mechanisms associated with normal physiological or abnormal pathological life activities.
the research was supported by projects such as the Ministry of Science and Technology, the National Natural Science Foundation of China and the Chinese Academy of Sciences. (Source: Institute of Zoology, Chinese Academy of Sciences.)