 Home > Medical News > Medical Science News > Scientists have discovered that gastric cancer immune escapes "minions"

Scientists have discovered that gastric cancer immune escapes "minions"

 Last Update: 2021-09-18
 Source: Internet
 Author: User

Tags

clinical research intern

fight cancer naturally

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Scientists have discovered that gastric cancer immune escapes "minions"

Scientists find "minions" for immune escape from gastric cancer Scientists find "minions" for immune escape from gastric cancer

Recently, the research team of Professor Xu Jiejie, School of Basic Medicine, Fudan University, in a large sample, multi-center study of 902 gastric cancer patients, found that the "CD73 protein" in the tumor tissues of gastric cancer patients can induce anti-tumor immunosuppression and immunotherapy resistance.
It plays a "disgraceful" role in gastric cancer and is the "claw" of gastric cancer immune escape.
At the same time, the expression of CD73 protein can be used as an important predictor of survival time and treatment sensitivity of gastric cancer patients, and is of great significance for guiding the individualized treatment of gastric cancer.

.

Related research results were published online in the European Journal of Cancer

According to Xu Jiejie, postoperative survival assessment, chemotherapy response prediction, and treatment options for patients insensitive to chemotherapy are the three major challenges in the clinical diagnosis and treatment of gastric cancer
.

In recent years, immunotherapy has gradually become an emerging tumor treatment method, and has achieved good results in many tumors

Xu Jiejie’s research team found that the CD73 protein in the immune microenvironment of gastric cancer can "instigate" the "warriors" of killing tumors-CD8 ⁺ T cells, induce them to up-regulate the expression of the inhibitory receptor PD-1, and reduce the anti-tumor immune function The secretion of the key factor of the disease makes the immune response that can effectively kill the tumor appear "immune brake", which leads to the immune escape of gastric cancer and the poor prognosis of the patient
.

Interestingly, although gastric cancer patients with high expression of CD73 protein have a worse prognosis, they are more responsive to postoperative adjuvant chemotherapy, while patients with gastric cancer with low expression of CD73 protein are receiving pembrolizumab drug immunotherapy A better curative effect was obtained at the time, which suggests that CD73 protein may become a companion diagnostic marker for adjuvant chemotherapy and immunotherapy for gastric cancer

⁺

Experts said that the study proposed for the first time that the CD73 protein in the tumor tissues of gastric cancer patients can be used as a new prognostic marker, potential immunotherapy target, and a guide factor for individualized medications for gastric cancer patients.
Development provides new ideas
.

(Source: Sun Guogen and Huang Xin)