Scientists have mapped the most accurate human RNA molecule m6A modification

reporter learned from the University of Liverpool, the university's Department of Biological Sciences, led by Dr. Meng Jia's research team, recently achieved a full transcription group RNA molecule m
The most accurate prediction of A modification is equivalent to the most accurate m
A surface transcription modification map ever made by humans. Further research may reveal the link between genetic features and certain major diseases in humans. The findings were published recently in Nucleic Acids Research, a leading journal in the field of bioinfocus.
, "RNA modification" refers to biochemical modification that occurs in RNA molecules, changing its properties without altering the RNA molecular sequence information and regulating the expression of genetic information. "There are currently more than 100 known RNA modifications,
m-A modifications are among the highest." Meng Jia explains.
recently, studies have shown that m is
ARNA methylated modified enzymes play a key role in leukemia, glioblastoma, non-small cell lung cancer, breast cancer and other diseases. Meng Jia introduced.
Mengjia points out that in the field of RNA modification, the team at the University of Liverpool is the first to use 35 histological information to make predictions. "Previous studies have only considered sequence information, with an accuracy of 80 percent, and on that basis we added 35 other histological information to improve accuracy to 90 percent, which is a relatively large breakthrough." Meng Jia added.
, according to the research team member, Xipu Department of Biological Sciences Ph.D. student Chen Qi, in the
In the process of a surface transcription group map, the team used machine learning techniques to train predictive models through existing features, which provided more reliable reference information for future research in the field of human RNA modification. (Source: Xinhua News Agency,