Scientists have revealed the dual mechanism of TRIM35 anti-flu virus

recently, the National Avian Influenza Reference Laboratory of Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences made important progress in the study of the natural immune mechanism of TRIM family protein anti-flu virus, the results of which were published online in Protein and Cell. The study found that TRIM35 is a positive regulatory molecule produced by the retinal acid-induced gene I (RIG-I) signaling pathline mediated I. type interferon (IFN), and expounds the molecular mechanism of TRIM35 to inhibit influenza virus replication and disease.
study found that TRIM35 is a positive regulatory molecule of the natural immune vitamin acid-induced gene I signaling path, which can promote the production of type I interferon. In vivo experiments further confirmed that the influenza virus in the Trim35 gene knock-out mice in the replication of the titration significantly increased, the pathogenicity significantly increased.
in-depth study found that, on the one hand, TRIM35 inhibits influenza virus replication by ubiminizing the key molecule TRAF3 of the I-signaling pathline of the vitamin I, thereby promoting the formation of the VISA-TBK1 complex and the production of type I interferon.
On the other hand, influenza virus PB2 protein can inhibit the production of type I IFN by inhibiting the ubibin modification of TRAF3, however, TRIM35 inhibits the activity and virus replication of viral CYR protein complex by degrading it through ubimination modification of the influenza virus PB2 protein 736-bit.
, the study found that TRIM35 can play its anti-flu virus role through a dual mechanism, thus deepening the understanding of the host's natural immune system anti-flu virus mechanism.
Nan and Jiang Li, Ph.D. graduate students, are co-authors of the article, Chen Hulan, a member of the Chinese Academy of Sciences, and Li Xiangjun, a researcher at the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences, are the co-authors of the article. The research has been funded by projects such as the National Key Research and Development Program, the National Natural Science Foundation of China, the Natural Science Foundation of Heilongjiang Province and the Central Public Interest Research Institute. (Source: Li Chen, China Science Journal)
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