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Recently, for the first time, scientists used a pocket sequencer to sequence and stitch together the human genome.
researchers accomplished the feat using the MinION nanohole sequencer.
they read nearly 100 billion base pairs and analyzed a large amount of DNA.
the main user of this product is scientists, and the cost is only a thousand dollars.
other types of DNA sequencing equipment about the same size as office copiers.
authors wrote in the study, published in Nature Biotechnology, that sequencing of the human genome has become the standard for judging whether DNA sequencers are good or bad.
other gene sequencing methods read only about 100 base pairs at a time, while MinION, using nanoporous technology, can read gene sequences of up to 882,000 base pairs. Matthew Loose, of the University of Nottingham,
study, said: "There are a lot of surprises about this study.
we can sequence much more DNA than before.
" Loose and the other authors of the paper are funded by Oxford Nanopore Technologies, MinION's parent company.
the nanoporous technology starts with the voltage that passes through the micropores in the membrane.
the device drives DNA at voltage, altering the output signal and converting small changes into base pairs, which are then handed over to a computer for analysis.
so far, MinION's error rate (the base for which the wrong base was detected) is still high, or a few percentage points higher than other methods.
if the same sequence is repeatedly analyzed, better results will be achieved, but after processing a large amount of DNA, the order of the base pairs still has an error rate of one thousandth.
Loose says they are doing more to determine whether it is a problem with the accuracy of the device or because the machine misread the actual physical changes in the molecule itself.
, Loose says, the sequencing method also takes a lot of time, about 50,000 CPU time.
Us technology media site Ars Technica reports that some analytical software simply can't handle nanoporous readings.
but the time it took may be worth it, and the device managed to supplement 12 fragments of the human genome.
about 4 to 8 percent of the human genome still needs to be sequenced.
soon, smidgION, another of the company's devices, will be able to send sequencing results directly to your phone, and if you want to know what kind of yeast you have on your banana, it's still useful.
this study shows that DNA sequencing technology is advancing rapidly. "Our LEVEL of DNA detection and device portability are about to reach an incredible level,"
Loose said.
"