Scientists hope to rapidly develop vaccines through HIV fingerprinting

[China Pharmaceutical network technology trends] HIV is a major global public health problem The Centers for Disease Control and Prevention (CDC) estimates that as of the end of 2013, 1.2 million people in the United States were living with HIV, including one in eight people who did not know they had HIV Scientists hope that their new "fingerprinting" method, HIV, which uses sugar molecules to protect itself from attacks by the immune system, will continue to improve and accelerate its development into an effective vaccine Researchers from the Scripps Institute in La Jolla, California, reported in the journal Nature communications how they developed and tested their HIV fingerprinting tools According to the World Health Organization (who), HIV remains a major global public health problem To date, the virus has killed more than 35 million people Once HIV enters the body, it weakens the immune system HIV can damage and destroy immune cells - especially anti infective CD4 cells or T cells As a result, people will become more and more prone to various infections and diseases, including certain types of cancer Currently, HIV cannot be effectively treated, but it can be controlled by art Antiretroviral therapy (Art) can revolutionize the lives of people living with HIV and their communities if used properly and followed up It can keep them healthy and reduce the chance of infecting others AIDS is the stage of HIV infection - it takes two to 15 years to reach that stage, and of course it varies from person to person However, if HIV is diagnosed early and treated before it reaches its advanced stage, infected people can still expect to live a healthy, long-term and quality life The Centers for Disease Control and Prevention (CDC) estimates that as of the end of 2013, 1.2 million people in the United States were living with HIV, including one in eight people who did not know they had HIV Great progress has been made in the prevention and treatment of AIDS, but much remains to be done, including the search for vaccines The two big challenges for HIV vaccine developers are that HIV can escape the immune system very well, and it is always changing The idea of vaccines - to stimulate the immune system to produce new or more antibodies that target the site of infection - has been eliminated Vaccine developers believe that a good target for HIV cases is the glycoprotein envelope that encapsulates the virus and contains the mechanism by which the virus enters the host cell However, one of the reasons why HIV is so easy to revive is that its glycoprotein coating is covered with a layer of polysaccharide molecules This layer of polysaccharide molecules can help the virus avoid the immune system and prevent the antibody from attacking the glycoprotein envelope Tools to help vaccine developers deal with glycan coating are very useful This new study provides such a tool to analyze the pattern of glycoprotein polysaccharide This allows scientists to quickly capture "fingerprints" of the virus and determine if their developed vaccine is in place The new tools respond quickly, and the research team has developed algorithms that are much faster than the previous manual methods to analyze the results quickly Speed of analysis is important in this area because developers are always scrambling for time with alternative vaccines to counter rapidly evolving viruses.