Scientists hope to use genetically modified fruit flies to find best cancer treatment

When clinicians encounter cancer patients who are resistant to therapy, they usually need to look for non-standard drugs to help treat them; typically, researchers grow tumor tissue in the lab and then apply the drugs to see if they can reduce tumor growth, a time-consuming and costly processIn the study, researchers came up with a new method that promotes tumor-like tissue in fruit flies and then uses drugs for testing, which is very fast and inexpensiveto clarify whether the new method was feasible, the researchers recruited rectal cancer volunteers who had developed a therapeutic effect on the therapy, collected tumor samples from patients for analysis and identified nine genes that promote tumor growth, and then genetically modified the genomes of multiple fruit fly embryos and added nine tumor factors (the nine genes above) to the epithelial cells, which, when they matured, were given to study how the cancer-containing drugs affected the fruitresearchers say that less than 20 percent of fruit flies that are not given drugs do not reach the stage of maturation, and that giving fruit flies one of the 121 drugs does not have any effect on them; The survival rate of fruit flies increased from 30 per cent to 60 per cent, and when both drugs were given, the tumor in the patient's body shrinks by 45 per cent and remains in that state for up to 11 months;finally the researchers said the results of this paper are very exciting, and later we need to more in-depth research to determine whether the use of genetically modified fruit flies this new method is feasible, if it is feasible, researchers may be able to use fruit flies in the future to find new anti-cancer treatmentsoriginal origin:Erdem Bangi, Celina Ang, Peter Smibert, et alA personalized platform scras trametinib plus zoledronate for a patient with KRAS-mutant meta colora colora cancer, Science Advances (2019)DOI: 10.1126/sciadv.aav6528