Scientists reveal a new mechanism for ROS to regulate the occurrence of uveal melanoma

Recently, Professor Fan Xianqun’s team from the Ninth Hospital of Shanghai Jiaotong University School of Medicine has made important progress in the development of tumor nano-diagnostic and therapeutic reagents.

UM is the most common intraocular malignant tumor in adults.

Therefore, the researchers used different concentrations of carbon dot nanomaterials to induce UM cells to produce different levels of ROS, comprehensively analyzed whether it can have different effects on the occurrence and development of tumor cells, and explained the mechanism behind this phenomenon from the perspective of tumor metabolism.

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In order to explore the mechanism behind this phenomenon, the research team applied non-targeted metabolomics technology combined with the mRNA expression profile of glutamine metabolism-related genes and found that C-dots-induced ROS promotes glutamine metabolism and accelerates the metabolism of glutamine by activating the Akt/mTOR pathway.

Experts said that the study has very important reference value for the reasonable selection of safe concentration of nanomaterials in tumor diagnosis and treatment applications.

Related paper information: org/10.