Recently, the team of Liu Yu, a researcher at the Dalian Institute of Chemical Physics of the Chinese Academy of Sciences, and Liu Xiaojing, a professor at Shandong University, Wang Lei, a researcher at the Institute of Biophysics, Chinese Academy of Sciences, and Gao Zhenming, a professor at the Second Affiliated Hospital of Dalian Medical University The color-changing fluorescent probe quantitatively measures the internal polar microenvironment of a variety of disease-causing proteins in the cell
Researcher professor Misfolding and aggregation of proteins in cells can cause a variety of protein configuration diseases, such as Alzheimer's disease, Parkinson's disease, gradual freezing disease, and myocardial amyloidosis
Based on the previous research on multiple aggregated protein probes, the team further developed a class of fluorescent probes that are sensitive to both the polar microenvironment and aggregated proteins
Related paper information: https://doi.
https://doi.
org/10.
1002/anie.
202107943
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