Scientists successfully 3D bioprint functional vascularized mice with thyroid glands.

In 2015, a team of scientists from the Russian company 3D Bioprinting Solutions successfully printed the thyroid gland in 3D and transplanted it into a mouse.
now, scientists have made new progress in publishing a paper called "Bioprinting Functional VascularIzed Mouse Thyroid Structure."
thyroid can cause complex problems, it is a relatively simple structure in itself, making it easy to target 3D printing.
"the thyroid gland is an endocrine organ whose anatomy is relatively simple, with no complex catheter system, and consists essentially of thyroid follicles and vascular systems," the researchers explained.
researchers used a stand-free 3D printing technology and a self-converged tissue sphere.
they used thyroid spheres (TS) and urethyroid spheres (AS) as sources of thyroid and endoder cells, using a custom bioprinter to print the two spheres into a tight formation in a collagen hydrogel.
then, endopilators that are placed next to the thyroid sphere invade them and vascularize them.
the same time, epital cells from the thyroid cyst form follicles.
The bio-printer used in this process, called Fabion, was developed internally and consists of several functions, including an injection pump, a fluid chip, a loading piston, a capture piston, and a deposition piston (with a groove on top for liquid removal).
these components work together to ensure high accuracy in 3D printing, which can deposit a single tissue sphere at a time.
bio-printer also includes a heating and cooling system to better control the polymerization of collagen hydrogels.
3D-printed thyroid structure is cultured in collagen hydrogel for 4 days.
, the researchers then transplanted 3D-printed thyroids into mice with hypothyroidic thyroid disease and tested them at three and five weeks, respectively.
results showed a significant increase in thyroid hormone levels in mice, suggesting that the 3D-printed organ was indeed not insulting.
histological evaluation also showed that the bioprinted thyroid successfully matured and blended with other parts of the mouse.
plan to print a human thyroid in 3D in 2018 and will also work with the University of Lou to print a mini kidney using kidney tissue cell biology, according to the university.
, our method will be able to bioprint any human organ," the researchers said.
.