Recently, researcher Yang Chunhao, Zuo Jianping, and associate researcher He Shijun of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and others have synthesized a new class of betulinic acid derivatives.
Osteoarthritis is a highly disabling chronic degenerative bone and joint disease, with joint pain, joint deformity and dysfunction as the main clinical manifestations
The research team used pyrazolo betulinic acid as the starting point for structural modification, with the goal of improving its water solubility and osteoclast differentiation inhibitory activity, and synthesized a series of amino-substituted pyrazolo betulinic acid derivatives
First, the researchers screened and obtained an amino-substituted pyrazolo betulinic acid derivative compound with osteoclast differentiation inhibitory activity through the osteoclast precursor cell differentiation system25
Sodium iodoacetate (MIA)-induced osteoarthritis in rats is a classic therapeutic drug evaluation system
This research provides new ideas for the design and development of osteoarthritis treatment drugs.
Doctoral students Wang Jie and Wei Wenhui of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences are the co-first authors of the paper, and Yang Chunhao, He Shijun and Zuo Jianping are the co-corresponding authors
Chinese Academy of Sciences Related paper information: https://doi.
https://doi.
org/10.
1021/acs.
jmedchem.
1c01019
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
![3-bromodibenzo[b,d]thiophene](https://file.echemi.com/fileManage/upload/cas/822/bb4496d0-decc-11eb-89d6-0255ac100033.png)
