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Scientists used the F-19 MRI dual-modal probe to achieve accurate in vivo imaging of nitroreductase in lung cancer

 Last Update: 2023-02-01
 Source: Internet
 Author: User

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pancreatic cancer mri

journal computational chemistry

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Recently, the research team of Zhou Xin, a researcher at the Institute of Precision Measurement Science and Technology Innovation of the Chinese Academy of Sciences, designed and constructed a dual-modal molecular probe Nitrofluoride Cy7, which realized the 19F magnetic resonance and near-infrared fluorescence accurate imaging
of nitroreductase in living lung cancer.
The relevant research results were published in the journal German Applied Chemistry (Angew.
Chem.
Int.
Ed.
) and was selected as the VIP (Very Important Paper)
of this issue.

Nitroreductase (NTR) is an important biomarker widely used to evaluate tumor hypoxia
.
Although there are already some optical imaging methods for in vivo imaging of nitroreductase, the shortcomings such as the depth of tissue penetration and the low quantitative concentration limit its wide application
in clinical diagnosis.
¹⁹ F MRI can directly detect the ¹⁹F nucleus signal, and there is no background signal interference in in vivo imaging, and the signal intensity is proportional to the concentration of the exogenous probe, which has the potential to become a traditional ¹H MRI Complementary new technologies
in clinical applications.
In this system, FCy7-NO2 can not only be used as a fast-response near-infrared fluorescence-enhanced probe for the monitoring of nitroreductases in lung cancer, but also take advantage of the ^19FMRI chemical shift-sensitive properties of this molecule.
Selectively in vivo imaging
of nitroreductases in deep lung cancer.

The method proposed by ¹⁹F magnetic resonance/fluorescence dual-modal imaging for the precise imaging and quantitative analysis of nitroreductase in tumors can provide an important tool
for the accurate diagnosis of tumor markers.
At the same time, the content of nitroreductase can be used to distinguish between normal and hypoxic tumor tissues and quantitatively assess the degree of hypoxia, which is expected to provide new methods and technologies
for the biomedical field.

The research work is supported
by the Ministry of Science and Technology of the People's Republic of China, the National Natural Science Foundation of China and the Chinese Academy of Sciences.

Figure 1.
Probes can sensitively detect changes
in nitroreductase in living lung cancer over a wide concentration range.
Figure 2.
FCy7-NO2 identifies precise in situ lung cancer
by near-infrared fluorescence and ^19FMRI chemical shift imaging.

Source: Institute of Precision Measurement Science and Technology Innovation, Chinese Academy of Sciences

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